5-Amino-7-azaindole

Base Information

• Chemical Name: 5-Amino-7-azaindole
• CAS No.: 100960-07-4
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 29339900
• European Community (EC) Number: 801-191-0
• DSSTox Substance ID: DTXSID50471009
• Nikkaji Number: J2.242.849G
• Wikidata: Q72505675
• Mol file: 100960-07-4.mol

Synonyms:5-Amino-7-azaindole;100960-07-4;1H-pyrrolo[2,3-b]pyridin-5-amine;1H-Pyrrolo[2,3-b]pyridin-5-ylamine;MFCD06659683;5-AMINO-1H-PYRROLO[2,3-B]PYRIDINE;1H-PYRROLO[2,3-B]PYRIDINE-5-AMINE;SCHEMBL926536;pyrrolo[2,3-b]pyrid-5-ylamine;DTXSID50471009;PLWBENCHEUFMTN-UHFFFAOYSA-N;1H-Pyrrolo[2,3-b]pyridin 5-ylamine;AKOS005258953;PB34142;SB10023;DS-10600;SY063116;AM20050605;CS-0004120;FT-0649776;A16244;EN300-110281;1H-Pyrrolo[2,3-b]pyridin-5-ylamine, AldrichCPR;W-204392;F2163-0171;Z1198169609

Chemical Property of 5-Amino-7-azaindole

Chemical Property:

• Melting Point: 128-129 °C
• Refractive Index: 1.78
• Boiling Point: 361.7±35.0 °C(Predicted)
• PKA: 8.28±0.20(Predicted)
• PSA: 54.70000
• Density: 1.367 g/cm³
• LogP: 1.72630
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 133.063997236
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

99% ^*data from raw suppliers

5-Amino-7-azaindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC2=NC=C(C=C21)N

Technology Process of 5-Amino-7-azaindole

There total 11 articles about 5-Amino-7-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-nitro-1H-pyrrolo[2,3-b]pyridine (101083-92-5) → 1H-pyrrolo[2,3-b]pyridin-5-amine (100960-07-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; Inert atmosphere;

Reference yield: 63.0%

5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → 1H-pyrrolo[2,3-b]pyridin-5-amine (100960-07-4)

Guidance literature:

With ammonia; copper(II) sulfate; In water; in a sealed tube; Heating / reflux;

Reference yield: 38.0%

C9H10N2O → 1H-pyrrolo[2,3-b]pyridin-5-amine (100960-07-4)

Guidance literature:

With sodium azide; methanesulfonic acid; trifluoroacetic acid; In hexane; at 40 ℃; for 10h;

upstream raw materials:

5-nitro-1H-pyrrolo[2,3-b]pyridine

3-iodo-5-nitropyridin-2-ylamine

2-amino-5-nitro-3-[(trimethylsilyl)ethynyl]pyridine

7-Azaindole

Downstream raw materials:

2-chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

2-methyl-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

2-chloro-4-fluoro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

4-methyl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-isophthalamic acid tert-butyl ester

Refernces

• 1、 -. "Aromatic amine compound synthesis method". Paragraph 0267-0269. . Retrieved 2019/01/23.
• 2、 -. "NOVEL ULK1 INHIBITORS AND METHODS USING SAME". Page/Page column 145; 146. . Retrieved 2016/03/22.