4-Nitrophenyl 2-(4-isobutylphenyl)propanoate

Base Information

• Chemical Name: 4-Nitrophenyl 2-(4-isobutylphenyl)propanoate
• CAS No.: 193149-67-6
• Molecular Formula: C₁₉H₂₁NO₄
• Molecular Weight: 327.38
• Mol file: 193149-67-6.mol

Synonyms:4-Nitrophenyl 2-(4-isobutylphenyl)propanoate

Chemical Property of 4-Nitrophenyl 2-(4-isobutylphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-Nitrophenyl 2-(4-isobutylphenyl)propanoate

There total 1 articles about 4-Nitrophenyl 2-(4-isobutylphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + ibuprofen (15687-27-1,58560-75-1) → 4-Nitrophenyl 2-(4-isobutylphenyl)propanoate (193149-67-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In acetonitrile; Ambient temperature;

DOI:10.1002/jps.2600810210

Reference yield:

4-Nitrophenyl 2-(4-isobutylphenyl)propanoate (193149-67-6) → (S)-ibuprofen (51146-56-6,58560-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Candida antarctica lipase B RG₄₀₁ mutant; water / aq. phosphate buffer; acetonitrile / 16.5 h / 30 °C / pH 7.5 / Resolution of racemate; Enzymatic reaction

2: Candida antarctica lipase B SG₃₀₃ mutant; water / aq. phosphate buffer / 25 °C / pH 7.5 / Enzymatic reaction

With Candida antarctica lipase B RG₄₀₁ mutant; Candida antarctica lipase B SG₃₀₃ mutant; water; In aq. phosphate buffer; acetonitrile;

DOI:10.1021/ja310455t

Reference yield:

4-Nitrophenyl 2-(4-isobutylphenyl)propanoate (193149-67-6) → ibuprofen (15687-27-1,58560-75-1) + (S)-2-(4-Isobutyl-phenyl)-propionic acid 4-nitro-phenyl ester + (R)-2-(4-Isobutyl-phenyl)-propionic acid 4-nitro-phenyl ester

Guidance literature:

With Candida antarctica lipase B RG₄₀₁ mutant; water; In aq. phosphate buffer; acetonitrile; at 30 ℃; for 16.5h; pH=7.5; Reagent/catalyst; Time; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1021/ja310455t

upstream raw materials:

4-nitro-phenol

ibuprofen

Downstream raw materials:

ibuprofen

(S)-ibuprofen

C₂₁H₂₆O₂

Refernces

• 1、 Shanbhag,Crider,Gokhale,Harpalani,Dick. "Ester and amide prodrugs of ibuprofen and naproxen: Synthesis, anti- inflammatory activity, and gastrointestinal toxicity". . p. 149 - 154. Retrieved 2007/10/02.