3-FLUORO-6-NITRO-O-XYLENE

Base Information

• Chemical Name: 3-FLUORO-6-NITRO-O-XYLENE
• CAS No.: 1736-87-4
• Molecular Formula: C8H8FNO2
• Molecular Weight: 169.155
• Hs Code.: 2909309090
• Mol file: 1736-87-4.mol

Synonyms:o-Xylene,3-fluoro-6-nitro- (7CI,8CI);2,3-Dimethyl-4-fluoro-1-nitrobenzene;2,3-Dimethyl-4-fluoronitrobenzene;

Chemical Property of 3-FLUORO-6-NITRO-O-XYLENE

Chemical Property:

• Vapor Pressure: 0.0346mmHg at 25°C
• Melting Point: 39-42℃
• Refractive Index: 1.527
• Boiling Point: 155.2°Cat760mmHg
• Flash Point: 36.3°C
• PSA: 45.82000
• Density: 1.09g/cm³
• LogP: 2.87390
• Storage Temp.: Room temperature.

Purity/Quality:

99% ^*data from raw suppliers

1-Fluoro-2,3-dimethyl-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-6-NITRO-O-XYLENE

There total 1 articles about 3-FLUORO-6-NITRO-O-XYLENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

3-fluoro-o-xylene (443-82-3) → 2,3-dimethyl-4-fluoro-1-nitro-benzene (1736-87-4)

Guidance literature:

With nitric acid; acetic anhydride; at 0 ℃; for 0.583333h;

Reference yield: 57.0%

2,3-dimethyl-4-fluoro-1-nitro-benzene (1736-87-4) + oxalic acid diethyl ester (95-92-1) → 2-oxo-3-(3-fluoro-2-methyl-6-nitrophenyl)-propanoic acid ethyl ester (796069-44-8)

Guidance literature:

oxalic acid diethyl ester; With potassium tert-butylate; In diethyl ether; ethanol; at 20 ℃; for 0.0833333h;

2,3-dimethyl-4-fluoro-1-nitro-benzene; In diethyl ether; ethanol; at 20 ℃; for 1h;

Reference yield: 39.0%

2,3-dimethyl-4-fluoro-1-nitro-benzene (1736-87-4) + 2-amino-4-hydroxymethylpyridine (105250-17-7) → 4-((2,3-dimethyl-4-nitrophenoxy)methyl)pyridin-2-amine (1338815-31-8)

Guidance literature:

2-amino-4-hydroxymethylpyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1.08333h;

2,3-dimethyl-4-fluoro-1-nitro-benzene; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 20.0333h;

upstream raw materials:

3-fluoro-o-xylene

Downstream raw materials:

2,3-dimethyl-4-fluoroaniline

C₁₈H₁₉N₃O₂

2-oxo-3-(3-fluoro-2-methyl-6-nitrophenyl)-propanoic acid ethyl ester

4-(2,3-dimethyl-4-nitrophenoxy)pyridin-2-amine

Refernces