Technology Process of 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4--2,2-(ethylenedioxy)butane
There total 9 articles about 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4--2,2-(ethylenedioxy)butane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 100 percent / H2 / PtO2 / acetic acid / 18 h / 2327.2 Torr
2: 90 percent / 18 h / Ambient temperature
3: thionyl chloride / benzene / 1 h / Heating
4: diethyl ether / 1 h / 25 °C
5: HBr / diethyl ether
6: 91 percent / sodium azide / methanol; H2O / 3.5 h / Ambient temperature
7: p-toluenesulfonic acid / benzene / 6 h / Heating
8: H2 / 10percent Pd/C / 18 h / 517.1 Torr
9: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h
With
4-methyl-morpholine; thionyl chloride; sodium azide; hydrogen bromide; hydrogen; toluene-4-sulfonic acid;
platinum(IV) oxide; palladium on activated charcoal;
In
methanol; diethyl ether; water; acetic acid; benzene;
DOI:10.1021/jm00356a004
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / 18 h / Ambient temperature
2: thionyl chloride / benzene / 1 h / Heating
3: diethyl ether / 1 h / 25 °C
4: HBr / diethyl ether
5: 91 percent / sodium azide / methanol; H2O / 3.5 h / Ambient temperature
6: p-toluenesulfonic acid / benzene / 6 h / Heating
7: H2 / 10percent Pd/C / 18 h / 517.1 Torr
8: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h
With
4-methyl-morpholine; thionyl chloride; sodium azide; hydrogen bromide; hydrogen; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
methanol; diethyl ether; water; benzene;
DOI:10.1021/jm00356a004
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / sodium azide / methanol; H2O / 3.5 h / Ambient temperature
2: p-toluenesulfonic acid / benzene / 6 h / Heating
3: H2 / 10percent Pd/C / 18 h / 517.1 Torr
4: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h
With
4-methyl-morpholine; sodium azide; hydrogen; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
methanol; water; benzene;
DOI:10.1021/jm00356a004
