2-(2,6-dichloroanilino)-5-nitrophenylacetic acid

Base Information

• Chemical Name: 2-(2,6-dichloroanilino)-5-nitrophenylacetic acid
• CAS No.: 174316-61-1
• Molecular Formula: C₁₄H₁₀Cl₂N₂O₄
• Molecular Weight: 341.15
• Mol file: 174316-61-1.mol

Synonyms:2-(2,6-dichloroanilino)-5-nitrophenylacetic acid

Chemical Property of 2-(2,6-dichloroanilino)-5-nitrophenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(2,6-dichloroanilino)-5-nitrophenylacetic acid

There total 1 articles about 2-(2,6-dichloroanilino)-5-nitrophenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

diclofenac sodium (15307-79-6) → 2-(2,6-dichloroanilino)-5-nitrophenylacetic acid (174316-61-1)

Guidance literature:

With nitrated silica gel; In dichloromethane; for 0.0833333h; Ambient temperature;

DOI:10.1002/(SICI)1099-1344(199601)38:1<13::AID-JLCR807>3.0.CO;2-D

Reference yield: 95.0%

2-(2,6-dichloroanilino)-5-nitrophenylacetic acid (174316-61-1) → 2-(2,6-dichloroanilino)-5-aminophenylacetic acid (174316-62-2)

Guidance literature:

With hydrogen; potassium carbonate; platinum(IV) oxide; In methanol; for 3h; under 2327.2 Torr;

DOI:10.1002/(SICI)1099-1344(199601)38:1<13::AID-JLCR807>3.0.CO;2-D

Reference yield:

2-(2,6-dichloroanilino)-5-nitrophenylacetic acid (174316-61-1) → 2-(2,6-dichloroanilino)-5-azidophenylacetic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / K₂CO₃, H₂ / PtO₂ / methanol / 3 h / 2327.2 Torr

2: 1.) aq. HCl, NaNO₂, 2.) NaN₃

With hydrogenchloride; sodium azide; hydrogen; potassium carbonate; sodium nitrite; platinum(IV) oxide; In methanol;

DOI:10.1002/(SICI)1099-1344(199601)38:1<13::AID-JLCR807>3.0.CO;2-D

upstream raw materials:

diclofenac sodium

Downstream raw materials:

2-(2,6-dichloroanilino)-5-aminophenylacetic acid

Refernces