N - (tert - butoxycarbonyl) - ± - Methylalanine Methyl ester

Base Information

• Chemical Name: N - (tert - butoxycarbonyl) - ± - Methylalanine Methyl ester
• CAS No.: 84758-55-4
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.265
• Mol file: 84758-55-4.mol

Synonyms:N-(tert-butoxycarbonyl)-α-methylalanine methyl ester

Chemical Property of N - (tert - butoxycarbonyl) - ± - Methylalanine Methyl ester

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-[(tert-butoxycarbonyl)amino]-2-methylpropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N - (tert - butoxycarbonyl) - ± - Methylalanine Methyl ester

There total 11 articles about N - (tert - butoxycarbonyl) - ± - Methylalanine Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc-Aib-OH (30992-29-1) + dimethyl sulfate (77-78-1) → N-(tert-butoxycarbonyl)-α-methylalanine methyl ester (84758-55-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jo990035l

Reference yield: 99.0%

methanol (67-56-1) + Boc-Aib-OH (30992-29-1) + diazomethyl-trimethyl-silane (18107-18-1) → N-(tert-butoxycarbonyl)-α-methylalanine methyl ester (84758-55-4)

Guidance literature:

In hexane; dichloromethane; at 20 ℃; for 2.5h;

Reference yield: 96.6%

Boc-Aib-OH (30992-29-1) + methyl iodide (74-88-4) → N-(tert-butoxycarbonyl)-α-methylalanine methyl ester (84758-55-4)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; for 5h; Ambient temperature;

DOI:10.1016/0040-4039(96)01597-3

upstream raw materials:

N-(tert-butyloxycarbonyl) azide

2-amino-2-methylpropionic acid methyl ester

α-Isocyanatobuttersaeure-methylester

tert-butyl alcohol

Downstream raw materials:

Boc-Aib-OH

methyl 2-aminoisobutyrate hydrochloride

N-tert-butoxycarbonyl-N-methyl-α-aminoisobutyric acid

C₂₁H₂₉N₅O₄

Refernces

• 1、 -. "INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE". Page/Page column 349. . Retrieved 2018/06/30.
• 2、 -. "INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE". Page/Page column 349. . Retrieved 2017/09/02.