L-Aspartic acid 4-cyclohexyl ester

Base Information

• Chemical Name: L-Aspartic acid 4-cyclohexyl ester
• CAS No.: 112259-66-2
• Molecular Formula: C10H17NO4
• Molecular Weight: 215.249
• Mol file: 112259-66-2.mol

Synonyms:Asparticacid b-cyclohexyl ester;b-Cyclohexyl aspartate;H-Asp(OcHex)-OH;

Chemical Property of L-Aspartic acid 4-cyclohexyl ester

Chemical Property:

• Vapor Pressure: 4.89E-07mmHg at 25°C
• Refractive Index: 1.51
• Boiling Point: 386.2 °C at 760 mmHg
• PKA: 2.17±0.23(Predicted)
• Flash Point: 187.4 °C
• PSA: 89.62000
• Density: 1.2 g/cm³
• LogP: 1.36460
• Storage Temp.: Store at 0°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Aspartic acid beta-cyclohexyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Aspartic acid 4-cyclohexyl ester

There total 4 articles about L-Aspartic acid 4-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

dicyclohexyl L-aspartate (121329-70-2) → β-cyclohexyl L-aspartate (112259-66-2) + α-cyclohexyl L-aspartate (121329-73-5)

Guidance literature:

With phosphate buffer; subtilisin; pH 7;

DOI:10.1021/jo00278a044

Reference yield: 39.0%

L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + cyclohexanol (108-93-0) → β-cyclohexyl L-aspartate (112259-66-2)

Guidance literature:

With tetrafluoroboric acid diethyl ether; sodium sulfate; at 60 ℃; for 15h;

DOI:10.1055/s-1987-28030

Reference yield:

Boc-Asp(O-cyclohexyl)-OH (73821-95-1) → β-cyclohexyl L-aspartate (112259-66-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.75h; Ambient temperature;

DOI:10.1021/jm9508043

upstream raw materials:

dicyclohexyl L-aspartate

L-Aspartic acid

cyclohexanol

Boc-Asp(O-cyclohexyl)-OH

Downstream raw materials:

Boc-Asp(O-cyclohexyl)-OH

N^α-trityl-L-aspartic acid β-cyclohexyl ester

C₁₂H₂₁NO₄

N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester

Refernces

• 1、 Stuhr-Hansen, Nicolai,Padrah, Shahrokh,Str?mgaard, Kristian. "Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids". supporting information. p. 4149 - 4151. Retrieved 2015/02/02.
• 2、 DeGraw, Joseph I.,Almquist, Ronald G.,Hiebert, Charles K.,Judd, Amrit K.,Dousman, Linda,Smith, R. Lane,Waud, William R.,Uchida, Itsuo. "Stabilized analogs of thymopentin. 2. 1,2- and 3,4-ketomethylene pseudopeptides". . p. 2398 - 2406. Retrieved 2007/10/03.