Ethyl Piperidine-2-carboxylate hydrochloride

Base Information

• Chemical Name: Ethyl Piperidine-2-carboxylate hydrochloride
• CAS No.: 77034-33-4
• Molecular Formula: C8H15NO2^.HCl
• Molecular Weight: 193.674
• Hs Code.: 2933399090
• European Community (EC) Number: 628-101-0
• DSSTox Substance ID: DTXSID00498201
• Mol file: 77034-33-4.mol

Synonyms:Ethyl Piperidine-2-carboxylate hydrochloride;77034-33-4;Ethyl pipecolinate hydrochloride;Ethyl pipecolinate HCl;ethyl piperidine-2-carboxylate;hydrochloride;MFCD00134518;MFCD09264372;Ethylpiperidine-2-carboxylatehydrochloride;Ethyl 2-piperidinecarboxylate hydrochloride;Piperidine-2-carboxylic acid ethyl ester hydrochloride;SCHEMBL1282288;DTXSID00498201;KGAWPIXNSIYQPC-UHFFFAOYSA-N;CDA03433;AKOS015897854;Ethyl pipecolinate hydrochloride, 97%;SB42965;SB43070;SB45089;ETHYL PIPERIDINE-2-CARBOXYLATE HCL;SY023683;SY107101;AM20100763;CS-0042722;FT-0641631;EN300-19559;ethyl 1-piperidine-2-carboxylate hydrochloride;A838946;2-piperidinecarboxylic acid ethyl ester hydrochloride;Ethyl piperidine-2-carboxylate--hydrogen chloride (1/1);Z104474224

Chemical Property of Ethyl Piperidine-2-carboxylate hydrochloride

Chemical Property:

• Vapor Pressure: 0.014mmHg at 25°C
• Melting Point: 211-213 °C
• Boiling Point: 254 °C at 760 mmHg
• Flash Point: 107.4 °C
• PSA: 38.33000
• LogP: 1.82240
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 193.0869564
• Heavy Atom Count: 12
• Complexity: 136

Purity/Quality:

≥98% ^*data from raw suppliers

EthylPiperidine-2-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-36/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1CCCCN1.Cl
• Uses: Ethyl pipecolinate hydrochloride (Ethyl 2-piperidinecarboxylate hydrochloride) may be used in the preparation of:1,4-diazabicyclo[4.4.0]decanesmall molecule inhibitors of Legionella MIP proteinantiinflammatory and analgesic moleculesanti-amnesic agents

Technology Process of Ethyl Piperidine-2-carboxylate hydrochloride

There total 5 articles about Ethyl Piperidine-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethanol (64-17-5) + pipecolic Acid (4043-87-2,83680-83-5) → ethyl piperidine-2-carboxylate hydrochloride (77034-33-4)

Guidance literature:

With hydrogenchloride; for 24h; Ambient temperature;

Reference yield: 92.0%

ethyl 1-benzyl-1,2,3,6-tetrahydropyridine-2-carboxylate (1258422-20-6) → ethyl piperidine-2-carboxylate hydrochloride (77034-33-4)

Guidance literature:

ethyl 1-benzyl-1,2,3,6-tetrahydropyridine-2-carboxylate; With 5% Pd(II)/C(eggshell); hydrogen; In methanol; at 20 ℃; for 4h;

pH=2;

DOI:10.1134/S1070428010090022

Reference yield: 87.0%

ethyl 1-ethoxycarbonyl-2-piperidinecarboxylate (33191-01-4) → ethyl piperidine-2-carboxylate hydrochloride (77034-33-4)

Guidance literature:

ethyl 1-ethoxycarbonyl-2-piperidinecarboxylate; With trimethylsilyl iodide; In chloroform; for 24h; Inert atmosphere; Reflux;

With ethanol; In chloroform; for 3h; Inert atmosphere; Reflux;

With hydrogenchloride; In ethanol; chloroform; water; Inert atmosphere;

DOI:10.1002/chem.201402514

upstream raw materials:

ethanol

pipecolic Acid

ethyl 1-benzyl-1,2,3,6-tetrahydropyridine-2-carboxylate

ethyl 1-ethoxycarbonyl-2-piperidinecarboxylate

Downstream raw materials:

1-[(4-methoxyphenyl)methyl]piperidine-2-carboxylic acid ethyl ester

ethyl N-(3-chlorophenylmethyl)pipecolinate

trans-Perhydroquinolizin-1(a)-ol

trans-Perhydroquinolizin-1(e)-ol

Refernces

• 1、 Korch, Katerina M.,Eidamshaus, Christian,Behenna, Douglas C.,Stoltz, Brian M.,Nam, Sangkil,Horne, David. "Enantioselective synthesis of α-secondary and α-tertiary piperazin-2- Ones and piperazines by catalytic asymmetric allylic alkylation". supporting information. p. 179 - 183. Retrieved 2015/02/05.
• 2、 Titanyuk,Beletskaya. "Synthesis of non-natural cyclic amino acids from available unsaturated tertiary amines". experimental part. p. 1277 - 1281. Retrieved 2010/12/19.