H-CHA-OH HCL

Base Information

• Chemical Name: H-CHA-OH HCL
• CAS No.: 25528-71-6
• Molecular Formula: C9H17NO2.ClH
• Molecular Weight: 207.7
• Mol file: 25528-71-6.mol

Synonyms:Cyclohexanepropanoicacid, a-amino-, hydrochloride, (S)-;Cyclohexanepropanoic acid, a-amino-,hydrochloride, (aS)- (9CI);Cyclohexanepropionic acid, a-amino-,hydrochloride, L- (8CI);(S)-2-Amino-3-cyclohexylpropanoic acid hydrochloride;L-Cyclohexylalanine-hydrochloride;

Chemical Property of H-CHA-OH HCL

Chemical Property:

• Melting Point: 232-237℃ (DEC.)
• PSA: 63.32000
• LogP: 2.87100
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-Amino-3-cyclohexylpropanoicacidhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-CHA-OH HCL

There total 12 articles about H-CHA-OH HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

(S)-2-acetylamino-3-cyclohexylpropionic acid (100400-96-2,97290-54-5) → (S)-2-amino-3-cyclohexylpropionic acid hydrochloride (25528-71-6)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.7164/antibiotics.49.909

Reference yield: 94.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → (S)-2-amino-3-cyclohexylpropionic acid hydrochloride (25528-71-6)

Guidance literature:

With hydrogenchloride; hydrogen; rhodium on carbon; In water; at 60 ℃; for 48h; under 2585.81 Torr;

Reference yield: 81.0%

methyl 3-cyclohexyl-L-alaninate hydrochloride (17193-39-4,144644-00-8) → (S)-2-amino-3-cyclohexylpropionic acid hydrochloride (25528-71-6)

Guidance literature:

With hydrogenchloride; for 24h; Reflux;

DOI:10.1021/op0200773

upstream raw materials:

<(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl> (2S)-2-amino-3-cyclohexylpropionate

(S)-2-acetylamino-3-cyclohexylpropionic acid

methyl L-cyclohexylalaninate

L-phenylalanine

Downstream raw materials:

methyl 3-cyclohexyl-L-alaninate hydrochloride

2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

Refernces

• 1、 Ager, David J.,Prakash, Indra. "Reductions of aromatic amino acids and derivatives". . p. 164 - 167. Retrieved 2013/09/05.
• 2、 -. "Pyrrolidine derivatives". . . Retrieved 2008/06/13.