Boc-8-Aoc-OH

Base Information Edit

Chemical Name:Boc-8-Aoc-OH
CAS No.:30100-16-4
Molecular Formula:C13H25 N O4
Molecular Weight:259.346
Hs Code.:2924199090
European Community (EC) Number:856-207-9
DSSTox Substance ID:DTXSID30338080
Nikkaji Number:J409.504I
Wikidata:Q82106263
Mol file:30100-16-4.mol

Synonyms:Boc-8-Aoc-OH;30100-16-4;Boc-8-aminooctanoic acid;8-(Boc-amino)octanoic acid;8-[(2-methylpropan-2-yl)oxycarbonylamino]octanoic acid;8-((tert-butoxycarbonyl)amino)octanoic acid;MFCD00270350;Boc-8-Aoc-OH Boc-8-aminocaprylic acid;8-(tert-Butoxycarbonylamino)octanoic acid;N-t-Butyloxycarbonyl-8-amino-octanoic acid;8-{[(tert-butoxy)carbonyl]amino}octanoic acid;8-Aminooctanoic acid, N-BOC-;Octanoicacid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-;Boc-Aoc(8)-OH;BocNH(CH2)7CO2H;8-(Boc-amino)caprylic acid;Boc-NH-(CH2)7-COOH;N-Boc-8-amino-octanoic acid;SCHEMBL826755;BOC-8-AMINOCAPRYLICACID;DTXSID30338080;Boc-8-Aoc-OH, >=97.0%;8-(t-butoxycarbonylamino)caprylic acid;8-tert-butoxycarbonylaminooctanoic acid;AKOS015998962;CS-W022596;8-(t-Butoxycarbonyl)amino-octanoic acid;8-(tert-butoxycarbonylamino)caprylic acid;AS-18273;BP-28243;SY066382;8-Aminooctanoic acid, N-t-butoxycarbonyl-;FT-0679718;8-[(tert-Butoxycarbonyl)amino]octanoic acid #;EN300-264166;A876304

Suppliers and Price of Boc-8-Aoc-OH

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Boc-8-aminocaprylic acid
1g
$ 366.00

TRC
Boc-8-Aoc-OH
100mg
$ 60.00

TRC
Boc-8-Aoc-OH
50mg
$ 45.00

Sigma-Aldrich
Boc-8-Aoc-OH ≥97.0%
1g
$ 147.00

Matrix Scientific
Boc-8-aminooctanoic acid
1g
$ 39.00

Matrix Scientific
Boc-8-aminooctanoic acid
5g
$ 109.00

Iris Biotech GmbH
Boc-8-Aoc-OH
1 g
$ 87.75

Iris Biotech GmbH
Boc-8-Aoc-OH
5 g
$ 324.00

Crysdot
Boc-8-Aoc-OH 97%
10g
$ 181.00

Chemenu
Boc-8-aminooctanoicacid 97%
100g
$ 879.00

Total 36 raw suppliers

Chemical Property of Boc-8-Aoc-OH Edit

Chemical Property:

Melting Point:56-59oC
Boiling Point:406.0±28.0 °C(Predicted)
PKA:4.78±0.10(Predicted)
PSA：75.63000
Density:1.036±0.06 g/cm3(Predicted)
LogP:3.32720
Storage Temp.:Store at 0°C
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:259.17835828
Heavy Atom Count:18
Complexity:258

Purity/Quality:

99.3% ^*data from raw suppliers

Boc-8-aminocaprylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCCCCCCCC(=O)O
Description Boc-8-aoc-oh can be used as a PROTAC linker in the synthesis of PROTACs. Boc-8-aoc-oh is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses Reagent to introduce a protected w-amino alkyl spacer. Longer spacer arms often impart increased activity to the substrate

Technology Process of Boc-8-Aoc-OH

There total 11 articles about Boc-8-Aoc-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%