2-Amino-2-(thiophen-3-yl)acetic acid

Base Information

• Chemical Name: 2-Amino-2-(thiophen-3-yl)acetic acid
• CAS No.: 38150-49-1
• Molecular Formula: C6H7NO2S
• Molecular Weight: 157.193
• Hs Code.: 2934999090
• European Community (EC) Number: 830-278-6
• DSSTox Substance ID: DTXSID60922951
• ChEMBL ID: CHEMBL1173786
• Mol file: 38150-49-1.mol

Synonyms:38150-49-1;2-Amino-2-(thiophen-3-yl)acetic acid;Amino-thiophen-3-yl-acetic acid;2-Amino-2-(3-thienyl)acetic acid;DL-alpha-(3-Thienyl)glycine;2-amino-2-thiophen-3-ylacetic acid;MFCD00079616;(2R)-2-amino-2-thiophen-3-ylacetic acid;2-(3-Thienyl)glycine;amino(thien-3-yl)acetic acid;amino(thiophen-3-yl)acetic acid;EINECS 214-788-0;IMIPRAMINEN-OXIDE;dl-a-(3-thienyl)glycine;Bionet2_000777;dl-2-(3-Thienyl)glycine;SCHEMBL352655;a-Amino-3-thiopheneacetic acid;Amino(3-thienyl)acetic acid #;CHEMBL1173786;DTXSID60922951;HMS1366D07;BCP11589;(S)-a-Amino-3-thiopheneacetic acid;2-Amino-2-(thiophen-3-yl)aceticacid;AKOS000172363;AKOS016340047;4L-303S;AB88408;AB89434;AC-6728;CS-W002336;HY-W002336;ALPHA-AMINO-3-THIOPHENEACETIC ACID;PD151354;SY025903;A6473;FT-0600301;FT-0649685;FT-0652675;EN300-88018;J-505833

Chemical Property of 2-Amino-2-(thiophen-3-yl)acetic acid

Chemical Property:

• Melting Point: 238℃
• Boiling Point: 317.5 °C at 760 mmHg
• PKA: 1.89±0.10(Predicted)
• Flash Point: 145.8 °C
• PSA: 91.56000
• Density: 1.418g/cm³
• LogP: 1.53280
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: -2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 157.01974964
• Heavy Atom Count: 10
• Complexity: 140

Purity/Quality:

99% ^*data from raw suppliers

Amino-thiophen-3-yl-aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC=C1C(C(=O)O)N

Technology Process of 2-Amino-2-(thiophen-3-yl)acetic acid

There total 7 articles about 2-Amino-2-(thiophen-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(2R)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure (97036-30-1) → D-(-)-2-(3-Thienyl)-glycin (1194-86-1,1194-87-2,1194-88-3,38150-49-1)

Guidance literature:

With ammonium hydroxide; periodic acid; In water; Ambient temperature;

Reference yield: 50.0%

(2S)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure (97101-16-1) → L-(+)-2-(3-Thienyl)glycin (1194-86-1,1194-87-2,1194-88-3,38150-49-1)

Guidance literature:

With ammonium hydroxide; periodic acid; In water; Ambient temperature;

Reference yield:

3-thiophene carboxaldehyde (498-62-4) → L-(+)-2-(3-Thienyl)glycin (1194-86-1,1194-87-2,1194-88-3,38150-49-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) CH₃OH, 20 min., room temp.; 2) acetic acid, -5 degC, 2 h, -5 degC to room temp., 20 h

2: 66 percent / conc. HCl / 1) -10 degC, 1 h; 2) 0 degC, 1 h; 3) room temp., 1 h; 4) 50 degC, 4 h

3: 50 percent / periodinic acid, 2 N NH₃ / H₂O / Ambient temperature

With hydrogenchloride; ammonium hydroxide; periodic acid; In water;

upstream raw materials:

(2S)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure

3-thiophene carboxaldehyde

(4S,5S)-(+)-2,2-Dimethyl-4-phenyl-5-<(3-thienylmethylen)amino>-1,3-dioxan

(2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(3-thienyl)acetonitril

Downstream raw materials:

(±)-2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)acetic acid

C₁₃H₁₁ClN₂O₃S

2-amino-2-(thiophen-3-yl)ethan-1-ol

N-<(o-nitrophenyl)sulfenyl>-D,L-3-thienylglycine (+)-β-fenchyl ester

Refernces