FMOC-L-LYS(DANSYL)-OH

Base Information

• Chemical Name: FMOC-L-LYS(DANSYL)-OH
• CAS No.: 118584-90-0
• Molecular Formula: C₃₃H₃₅N₃O₆S
• Molecular Weight: 601.723
• Mol file: 118584-90-0.mol

Synonyms:Fmoc-Lys(dansyl)-OH; N-(9-Fluorenylmethyloxycarbonyl)-N'-dansyl-L-lysine

Chemical Property of FMOC-L-LYS(DANSYL)-OH

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

Fmoc-Lys(dansyl)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fmoc-Lys(dansyl)-OH is a dansylated peptides as a substrate for fluorometric proteolytic enzyme assays.

Technology Process of FMOC-L-LYS(DANSYL)-OH

There total 1 articles about FMOC-L-LYS(DANSYL)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) + Fmoc-Lys-OH (105047-45-8) → N-α-Fmoc-N-ε-[5-(dimethylamino)naphthalene-1-sulfonyl]-L-lysine (118584-90-0)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane;

Reference yield:

C26H28N2O3 (1435485-68-9) + N-α-Fmoc-N-ε-[5-(dimethylamino)naphthalene-1-sulfonyl]-L-lysine (118584-90-0) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → C67H85N15O9S (1435485-71-4)

Guidance literature:

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 1.5h;

With piperidine; In N,N-dimethyl-formamide; Wang resin

C₂₆H₂₈N₂O₃; N-α-Fmoc-N-ε-[5-(dimethylamino)naphthalene-1-sulfonyl]-L-lysine; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;

DOI:10.1021/ml400073g

upstream raw materials:

5-(dimethylamino)naphth-1-ylsulfonyl chloride

Fmoc-Lys-OH

Downstream raw materials:

C₆₇H₈₅N₁₅O₉S

Refernces

• 1、 Chen, Yong-Xiang,Koch, Sebastian,Uhlenbrock, Katharina,Weise, Katrin,Das, Debapratim,Gremer, Lothar,Brunsveld, Luc,Wittinghofer, Alfred,Winter, Roland,Triola, Gemma,Waldmann, Herbert. "Synthesis of the Rheb and K-Ras4B GTPases". supporting information; experimental part. p. 6090 - 6095. Retrieved 2010/11/18.