N-FMOC-IMINODIACETIC ACID

Base Information

• Chemical Name: N-FMOC-IMINODIACETIC ACID
• CAS No.: 112918-82-8
• Molecular Formula: C19H17 N O6
• Molecular Weight: 355.34138
• Hs Code.: 29242990
• Mol file: 112918-82-8.mol

Synonyms:N-(9-Fluorenylmethoxycarbonyl)iminodiaceticacid

Chemical Property of N-FMOC-IMINODIACETIC ACID

Chemical Property:

• Vapor Pressure: 3.77E-16mmHg at 25°C
• Melting Point: 213-217 °C
• Refractive Index: 1.635
• Boiling Point: 618.4°C at 760 mmHg
• PKA: 3.33±0.10(Predicted)
• Flash Point: 327.8°C
• PSA: 104.14000
• Density: 1.41g/cm³
• LogP: 2.40670
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Fmoc-iminodiaceticAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-FMOC-IMINODIACETIC ACID

There total 1 articles about N-FMOC-IMINODIACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + iminodiacetic acid (142-73-4) → 3-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid (112918-82-8)

Guidance literature:

With sodium hydrogencarbonate; In acetone; for 6h;

DOI:10.1021/jm00046a022

Reference yield:

Boc-NMe-Ala-Lys-Pro-BHA + 3-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid (112918-82-8) → C60H81N11O8

Guidance literature:

3-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid; With 4-methyl-morpholine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate; for 0.5h;

Boc-NMe-Ala-Lys-Pro-BHA; In N,N-dimethyl-formamide; Further stages;

DOI:10.1016/j.bmcl.2015.09.017

Reference yield:

Fmoc-Pro-OH (71989-31-6) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine (103213-32-7,167015-11-4) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + 9-fluorenylmethoxycarbonyl-Nim-trityl-L-histidine + 3-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid (112918-82-8) + 3-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid (557756-85-1,850312-72-0) + N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine (187618-60-6) → C69H109N21O18S

Guidance literature:

Fmoc-Lys(tert-butoxycarbonyl); With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 1h; Automated synthesizer;

With piperidine; In N,N-dimethyl-formamide; Automated synthesizer;

Fmoc-Pro-OH; N-Fmoc L-Phe; N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine; Fmoc-Thr(tBu)-OH; 9-fluorenylmethoxycarbonyl-Nim-trityl-L-histidine; 3-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid; 3-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid; N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-N^G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine; Further stages;

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

iminodiacetic acid

Refernces

• 1、 Kim, Hea Ok,Ji, Xiao-duo,Melman, Neli,Olah, Mark E.,Stiles, Gary L.,Jacobson, Kenneth A.. "Structure-Activity Relationships of 1,3-Dialkylxanthine Derivatives at Rat A3 Adenosine Receptors". . p. 3373 - 3382. Retrieved 2007/10/02.