ethyl tetrazolo[1,5-a]pyridine-7-carboxylate

Base Information

• Chemical Name: ethyl tetrazolo[1,5-a]pyridine-7-carboxylate
• CAS No.: 1582284-09-0
• Molecular Formula: C₈H₈N₄O₂
• Molecular Weight: 192.177
• Mol file: 1582284-09-0.mol

Synonyms:ethyl tetrazolo[1,5-a]pyridine-7-carboxylate

Chemical Property of ethyl tetrazolo[1,5-a]pyridine-7-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl tetrazolo[1,5-a]pyridine-7-carboxylate

There total 1 articles about ethyl tetrazolo[1,5-a]pyridine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoisonicotinic acid (66572-56-3) → ethyl tetrazolo[1,5-a]pyridine-7-carboxylate (1582284-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; hydrogenchloride / ethanol; water / 24 h / 120 °C / Sealed tube

2: sulfuric acid / 12 h / 100 °C

With hydrogenchloride; sodium azide; sulfuric acid; In ethanol; water;

DOI:10.1002/anie.201904702

Reference yield: 92.0%

ethyl tetrazolo[1,5-a]pyridine-7-carboxylate (1582284-09-0) + phenylacetylene (536-74-3) → C16H14N2O2

Guidance literature:

With meso-tetraphenylporphyrin iron(III) chloride; zinc; In benzene; at 100 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201904702

Reference yield: 81.0%

ethyl tetrazolo[1,5-a]pyridine-7-carboxylate (1582284-09-0) + phenylacetylene (536-74-3) → ethyl 2-(4-phenyl-1H-1,2,3-triazol-1-yl)isonicotinate (1582284-16-9)

Guidance literature:

With copper(I) trifluoromethanesulfonate benzene complex; In toluene; at 80 ℃; for 12h; Glovebox; Inert atmosphere;

DOI:10.1021/jo500231m

upstream raw materials:

2-bromoisonicotinic acid

Downstream raw materials:

ethyl 2-(4-phenyl-1H-1,2,3-triazol-1-yl)isonicotinate

Refernces