6-Ethylquinoline

Base Information

• Chemical Name: 6-Ethylquinoline
• CAS No.: 19655-60-8
• Molecular Formula: C₁₁H₁₁N
• Molecular Weight: 157.215
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID60343243
• Nikkaji Number: J47.681A
• Wikidata: Q63395378
• Mol file: 19655-60-8.mol

Synonyms:6-Ethylquinoline;19655-60-8;Quinoline, 6-ethyl-;SCHEMBL11833;DTXSID60343243;AKOS006279770;SB67641;FT-0676590;Q63395378

Chemical Property of 6-Ethylquinoline

Chemical Property:

• Vapor Pressure: 0.0126mmHg at 25°C
• Melting Point: 51.53°C (estimate)
• Refractive Index: 1.608
• Boiling Point: 268.6°Cat760mmHg
• PKA: 5.18±0.10(Predicted)
• Flash Point: 110.4°C
• PSA: 12.89000
• Density: 1.05g/cm³
• LogP: 2.79720
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 157.089149355
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

98.5% ^*data from raw suppliers

6-ETHYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

• Canonical SMILES: CCC1=CC2=C(C=C1)N=CC=C2

Technology Process of 6-Ethylquinoline

There total 5 articles about 6-Ethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + 4-aminoethylbenzene (589-16-2) → 6-ethylquinoline (19655-60-8)

Guidance literature:

With tungstic acid functionalized KIT-6; In water; at 200 ℃; for 3h; Autoclave;

Reference yield: 93.0%

2-propionylpyridine (3238-55-9) + 6-bromoquinoline (5332-25-2) → 6-ethylquinoline (19655-60-8)

Guidance literature:

With 2.9-dimethyl-1,10-phenanthroline; palladium(II) trifluoroacetate; potassium tert-butylate; In toluene; at 120 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02498

Reference yield: 78.0%

6-bromoquinoline (5332-25-2) + 1-(3-methoxyphenyl)propan-1-one (37951-49-8) → 6-ethylquinoline (19655-60-8)

Guidance literature:

With 2.9-dimethyl-1,10-phenanthroline; palladium(II) trifluoroacetate; potassium tert-butylate; In toluene; at 120 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02498

upstream raw materials:

glycerol

4-aminoethylbenzene

trimethyleneglycol

2-propionylpyridine

Refernces

• 1、 -. "Preparation method of quinoline derivative". Paragraph 0109; 0110. . Retrieved 2017/06/02.
• 2、 Udayakumar,Pandurangan. "Synthesis of quinolines from glycerol over tungstic acid functionalized mesoporous KIT-6 catalyst in aqueous medium". . p. 919 - 928. Retrieved 2017/08/04.