(S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine hydrochloride

Base Information

• Chemical Name: (S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine hydrochloride
• CAS No.: 959392-22-4
• Molecular Formula: C₁₈H₁₉NOS
• Molecular Weight: 297.421
• Mol file: 959392-22-4.mol

Synonyms:(S)-(+)-N-methyl-3-(1-naphthalenyloxy)-3-(3-thienyl)propanamine

Chemical Property of (S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine hydrochloride

Chemical Property:

• Boiling Point: 466.2±40.0 °C(Predicted)
• PKA: 10.12±0.10(Predicted)
• Density: 1.158±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

(3S)-N-Methyl-γ-(1-naphthalenyloxy)-3-thiophenepropanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (γS)-N-Methyl-γ-(1-naphthalenyloxy)-3-thiophenepropanamine (Duloxetine EP Impurity F) is an impurity of Duloxetine (D721000), an antidepressant and a dual serotonin and norepinephrine reuptake inhibitor (SNRI) (1,2). Exhibits linear pharmacokinetics in mice and is not associated in any drastic changes of blood pressure or heart rate (3).

Technology Process of (S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine hydrochloride

There total 3 articles about (S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ (S)-(+)-N-methyl-3-(1-naphthalenyloxy)-3-(3-thienyl)propanamine (959392-22-4) + (R)-Duloxetine (116539-60-7) + duloxetine hydrochloride (136434-34-9)

Guidance literature:

In ethyl acetate; Purification / work up;

Reference yield: 87.0%

→ (S)-(+)-N-methyl-3-(1-naphthalenyloxy)-3-(3-thienyl)propanamine (959392-22-4) + duloxetine hydrochloride (136434-34-9)

Guidance literature:

In water; acetone; Purification / work up;

Reference yield: 68.0%

(R)-Duloxetine (116539-60-7) → (S)-(+)-N-methyl-3-(1-naphthalenyloxy)-3-(3-thienyl)propanamine (959392-22-4) + duloxetine hydrochloride (136434-34-9)

Guidance literature:

In water; acetone; Purification / work up;

upstream raw materials:

(R)-Duloxetine

Downstream raw materials:

duloxetine hydrochloride

Refernces