2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-ylamine

Base Information

• Chemical Name: 2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-ylamine
• CAS No.: 1644-86-6
• Molecular Formula: C₇H₄F₂N₂O₄
• Molecular Weight: 218.117
• Hs Code.: 2932999099
• Mol file: 1644-86-6.mol

Synonyms:Aniline,4,5-[(difluoromethylene)dioxy]-2-nitro- (7CI,8CI)

Chemical Property of 2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-ylamine

Chemical Property:

• Melting Point: 140-1410C
• Refractive Index: 1.593
• PSA: 90.30000
• LogP: 2.60290
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-ylamine (cas# 1644-86-6) is a compound useful in organic synthesis.

Technology Process of 2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-ylamine

There total 4 articles about 2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetamide (948-94-7) → 2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-amine (1644-86-6)

Guidance literature:

With nitronium tetrafluoborate; In sulfolane; dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2018.05.053

Reference yield:

N-(2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-yl)acetamide (1736-66-9) → 2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-amine (1644-86-6)

Guidance literature:

With methanol; sodium methylate; at 0 - 5 ℃; for 0.75h;

Reference yield:

2,2-difluoro-benzo[1,3]dioxol-5-ylamine (1544-85-0) → 2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-amine (1644-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 2 h / 100 °C

2: acetic acid; nitric acid / 25 - 60 °C

3: sodium methylate; methanol / 0.75 h / 0 - 5 °C

With methanol; nitric acid; sodium methylate; acetic acid; In toluene;

upstream raw materials:

2,2-difluoro-benzo[1,3]dioxol-5-ylamine

N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetamide

N-(2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-yl)acetamide

Downstream raw materials:

2,2-difluorobenzo[d][1,3]dioxole-5,6-diamine

Refernces

• 1、 -. "BIFLUORODIOXALANE-AMINO-BENZIMIDAZOLE KINASE INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNEINFLAMMATION AND CNS DISORDERS". . . Retrieved 2014/01/17.