1H-Benzimidazole,2-ethoxy-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,2-ethoxy-(9CI)
• CAS No.: 22219-23-4
• Molecular Formula: C9H10 N2 O
• Molecular Weight: 162.191
• Mol file: 22219-23-4.mol

Synonyms:Benzimidazole,2-ethoxy- (6CI,7CI,8CI); 2-Ethoxybenzimidazole

Chemical Property of 1H-Benzimidazole,2-ethoxy-(9CI)

Chemical Property:

• Melting Point: 165-166 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 170-171 °C(Press: 14 Torr)
• PKA: 10.81±0.10(Predicted)
• PSA: 37.91000
• Density: 1.196±0.06 g/cm3(Predicted)
• LogP: 1.96160
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Ethoxy-1H-benzo[d]imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,2-ethoxy-(9CI)

There total 5 articles about 1H-Benzimidazole,2-ethoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

orthocarbonic acid tetraethyl ester (78-09-1) + 1,2-diamino-benzene (95-54-5) → 2-ethoxy-1H-benzo[d]imidazole (22219-23-4)

Guidance literature:

orthocarbonic acid tetraethyl ester; 1,2-diamino-benzene; With acetic acid; at 70 ℃; for 2h;

With potassium hydroxide; In water; at 20 ℃; for 1h;

DOI:10.1021/acs.oprd.6b00108

Reference yield: 91.0%

orthocarbonic acid tetraethyl ester (78-09-1) + 2-nitro-aniline (88-74-4) → 2-ethoxy-1H-benzo[d]imidazole (22219-23-4)

Guidance literature:

With 10% Pd/C; hydrogen; acetic acid; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.3987/COM-08-11384

Reference yield:

diethyl imidocarbonate (2812-77-3) + o-phenylenediamine hydrochloride (39145-59-0) → 2-ethoxy-1H-benzo[d]imidazole (22219-23-4)

Guidance literature:

With water;

upstream raw materials:

diethyl imidocarbonate

o-phenylenediamine hydrochloride

orthocarbonic acid tetraethyl ester

1,2-diamino-benzene

Downstream raw materials:

1,3-dihydro-2H-benzimidazol-2-one

chloroethane

flibanserin

1-((2’-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole

Refernces

• 1、 Chen, Xin,Yang, Xi,Mao, Fei,Wei, Jinlian,Xu, Yixiang,Li, Baoli,Zhu, Jin,Ni, Shuaishuai,Jia, Lijun,Li, Jian. "Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo". . . Retrieved 2020/11/02.
• 2、 -. "SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS". Paragraph 00296; 00302; 00404. . Retrieved 2021/04/01.