2-amino-N-(1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide

Base Information Edit

Chemical Name:2-amino-N-(1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide
CAS No.:170115-96-5
Molecular Formula:C12H18 N2 O2
Molecular Weight:222.287
Hs Code.:
European Community (EC) Number:623-886-6
Mol file:170115-96-5.mol

Synonyms:(R,R)-(-)-PSEUDOEPHEDRINE GLYCINAMIDE;170115-96-5;pseudoephedrine glycinamide;3-methoxyphenylpropargylalcohol;SCHEMBL8561317;RASDPMXCBLHKCI-UHFFFAOYSA-N;2-amino-N-(1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide;HMS3329A21;HMS3336E06;STR08275;AKOS037655920;FT-0774119;(R)-2-(1-(7-Methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoicacid

Suppliers and Price of 2-amino-N-(1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S,S)-(+)-PseudoephedrineGlycinamide
250mg
$ 1260.00

Medical Isotopes, Inc.
(S,S)-(+)-PseudoephedrineGlycinamide
250 mg
$ 2200.00

Medical Isotopes, Inc.
(S,S)-(+)-PseudoephedrineGlycinamide
25 mg
$ 650.00

Total 6 raw suppliers

Chemical Property of 2-amino-N-(1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide Edit

Chemical Property:

Vapor Pressure:4.84E-07mmHg at 25°C
Melting Point:76-80 °C(lit.)
Refractive Index:1.56
Boiling Point:397.8°Cat760mmHg
PKA:13.71±0.20(Predicted)
Flash Point:194.4°C
PSA：66.56000
Density:1.14g/cm³
LogP:1.22590
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:222.136827821
Heavy Atom Count:16
Complexity:227

Purity/Quality:

98% ^*data from raw suppliers

(S,S)-(+)-PseudoephedrineGlycinamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C(C1=CC=CC=C1)O)N(C)C(=O)CN
Uses (S,S)-(+)-Pseudoephedrine Glycinamide is a commonly used precursor for the synthesis of α-amino acids.

Technology Process of 2-amino-N-(1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide

There total 13 articles about 2-amino-N-(1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 185508-77-4
{[((1S,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-methyl}-carbamic acid tert-butyl ester

: 170115-96-5
2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide

Guidance literature:: With hydrogenchloride; In methanol; at 0 ℃; for 3h; other solvent, reagent;
DOI:10.1021/ja9624073

Reference yield:

: 52289-93-7
o-Methoxybenzyl bromide

: 170115-96-5
2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, LiCl, 3.) aq. NaOH, 4.) aq. sodium bicarbonate

2: 1.) n-BuLi, LiCl

With sodium hydroxide; n-butyllithium; sodium hydrogencarbonate; lithium chloride; lithium diisopropyl amide;
DOI:10.1021/ja00137a034