2-acetamido-9,9-dimethylfluorene

Base Information

• Chemical Name: 2-acetamido-9,9-dimethylfluorene
• CAS No.: 63021-04-5
• Molecular Formula: C₁₇H₁₇NO
• Molecular Weight: 251.328
• Mol file: 63021-04-5.mol

Synonyms:2-acetamido-9,9-dimethylfluorene

Chemical Property of 2-acetamido-9,9-dimethylfluorene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-acetamido-9,9-dimethylfluorene

There total 1 articles about 2-acetamido-9,9-dimethylfluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9,9-dimethyl-9H-fluorene (4569-45-3) → 2-acetamido-9,9-dimethylfluorene (63021-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; HNO₃

2: zinc; acetic acid; CaCl₂ / in wss.Aethanol, und Behandeln des Reaktionsprodukts mit Acetanhydrid und Pyridin

With nitric acid; acetic acid; calcium chloride; zinc;

DOI:10.1002/hlca.19530360635

Reference yield:

2-acetamido-9,9-dimethylfluorene (63021-04-5) → 9,9-dimethyl-9H-fluoren-2-ylamine (108714-73-4)

Guidance literature:

With water; potassium hydroxide; In ethanol; xylene; for 36h; Product distribution / selectivity; Reflux;

Reference yield:

2-acetamido-9,9-dimethylfluorene (63021-04-5) → 12,12-dimethyl-11,12-dihydroindeno[2,1-a]carbazole (1260228-95-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: nitric acid / propionic acid / 1 h / -15 °C

2.1: hydrogenchloride / ethanol / 3 h / 115 °C

3.1: hydrogenchloride; sodium nitrite / dimethyl sulfoxide; water / 2.5 h / -5 - 25 °C

3.2: 20 h / -5 - 28 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 24 h / Inert atmosphere; Reflux

5.1: triphenylphosphine / 1,2-dichloro-benzene / 16 h / 195 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nitric acid; potassium carbonate; triphenylphosphine; sodium nitrite; In ethanol; water; dimethyl sulfoxide; propionic acid; 1,2-dichloro-benzene; toluene; 4.1: |Suzuki Coupling;

upstream raw materials:

9,9-dimethyl-9H-fluorene

Downstream raw materials:

9,9-dimethyl-9H-fluoren-2-ylamine

12,12-dimethyl-11,12-dihydroindeno[2,1-a]carbazole

3-amino-9,9’-dimethylfluorene

Refernces