4-chloro-N,N-diethyl-α-oxo-benzeneacetamide

Base Information

• Chemical Name: 4-chloro-N,N-diethyl-α-oxo-benzeneacetamide
• CAS No.: 84039-66-7
• Molecular Formula: C₁₂H₁₄ClNO₂
• Molecular Weight: 239.702
• Mol file: 84039-66-7.mol

Synonyms:4-chloro-N,N-diethyl-α-oxo-benzeneacetamide

Chemical Property of 4-chloro-N,N-diethyl-α-oxo-benzeneacetamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-chloro-N,N-diethyl-α-oxo-benzeneacetamide

There total 13 articles about 4-chloro-N,N-diethyl-α-oxo-benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-n-chlorophenylacetylene (873-73-4) + N,N-diethyl-O-benzoylhydroxylamine (61582-64-7) → 4-chloro-N,N-diethyl-α-oxo-benzeneacetamide (84039-66-7)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c6ra15219h

Reference yield: 80.0%

N-formyldiethylamine (617-84-5) + para-chloroacetophenone (99-91-2) → 4-chloro-N,N-diethyl-α-oxo-benzeneacetamide (84039-66-7)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; at 100 ℃; for 16h;

DOI:10.1039/c2cc35279f

Reference yield: 77.0%

4-chlorophenylglyoxylic acid (7099-88-9) + triethylamine (121-44-8) → 4-chloro-N,N-diethyl-α-oxo-benzeneacetamide (84039-66-7)

Guidance literature:

With silver (II) carbonate; dipotassium peroxodisulfate; In tetrachloromethane; N,N-dimethyl-formamide; at 120 ℃; for 12h;

DOI:10.1039/c3ob40619a

upstream raw materials:

bromochlorobenzene

carbon monoxide

diethylamine

1-Chloro-4-iodobenzene

Refernces

• 1、 Shen, Guodong,Zhao, Lingyu,Wang, Yichen,Zhang, Tongxin. "Room temperature copper-catalyzed oxidative amidation of terminal alkynes for the synthesis of α-ketoamides using: O -benzoyl hydroxylamines as aminating reagent and oxidant". . p. 78307 - 78310. Retrieved 2016/09/09.
• 2、 Behera, Ahalya,Ali, Wajid,Tripathy, Manisha,Sahoo, Diptimayee,Patel, Bhisma K.. "Transition metal-free synthesis of α-ketoamides from arylmethyl ketones and alkylphosphoramides". . p. 91308 - 91313. Retrieved 2016/10/09.