(R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate

Base Information

• Chemical Name: (R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate
• CAS No.: 957215-03-1
• Molecular Formula: C₂H₂O₄*C₃₆H₄₁N₃O₆
• Molecular Weight: 701.774
• Mol file: 957215-03-1.mol

Synonyms:(R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate

Chemical Property of (R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate

There total 1 articles about (R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.7%

(R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 1,1-dimethyl-2-methylaminoethyl methyl ester oxalate + oxalic acid (144-62-7,97993-78-7) + 3,3-diphenylpropyl 4-methylbenzenesulfonate (23808-47-1) → (R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate (957215-03-1)

Guidance literature:

(R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 1,1-dimethyl-2-methylaminoethyl methyl ester oxalate; 3,3-diphenylpropyl 4-methylbenzenesulfonate; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In toluene; at 78 - 82 ℃; for 24h;

oxalic acid; In tert-butyl methyl ether; isopropyl alcohol; at -15 - -10 ℃; for 1h;

Reference yield: 95.0%

(R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate (957215-03-1) → lercanidipine hydrochloride (132866-11-6,184866-29-3)

Guidance literature:

(R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate; With potassium carbonate; In dichloromethane; water;

With hydrogenchloride; In dichloromethane; water;

upstream raw materials:

oxalic acid

3,3-diphenylpropyl 4-methylbenzenesulfonate

Downstream raw materials:

lercanidipine hydrochloride

Refernces