norethisterone benzoate

Base Information

• Chemical Name: norethisterone benzoate
• CAS No.: 71203-39-9
• Molecular Formula: C₂₇H₃₀O₃
• Molecular Weight: 402.533
• Mol file: 71203-39-9.mol

Synonyms:norethisterone benzoate

Chemical Property of norethisterone benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of norethisterone benzoate

There total 6 articles about norethisterone benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

norethisterone (68-22-4) + benzoic acid (65-85-0,8013-63-6) → norethisterone benzoate (71203-39-9)

Guidance literature:

With sodium carbonate; trifluoroacetic anhydride; In benzene; for 3h; Ambient temperature;

DOI:10.1016/0039-128X(85)90027-3

Reference yield:

C29H34O4 → norethisterone benzoate (71203-39-9)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; at 28 ℃; for 48h; Yield given;

DOI:10.1016/0039-128X(83)90101-0

Reference yield:

norethisterone (68-22-4) → norethisterone benzoate (71203-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / Dowex 50 H+ / benzene / 14 h / Heating

2: n-BuLi / tetrahydrofuran; hexane / 5 h / Heating

3: p-TosOH / acetone / 48 h / 28 °C

With n-butyllithium; Dowex 50 H+; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; acetone; benzene;

DOI:10.1016/0039-128X(83)90101-0

upstream raw materials:

norethisterone

benzoic acid

benzoyl chloride

norethisterone 3-ethyleneketal

Refernces

• 1、 Wan, A. S. C.,Ngiam, T. L.,Leung, S. L.,Go, M. L.,Heng, P. W. S.,et al.. "LONG-ACTING CONTRACEPTIVE AGENTS: NORETHISTERONE ESTERS OF ARYLCARBOXYLIC ACIDS". . p. 309 - 320. Retrieved 2007/10/02.