(+)-CIS-TRAMADOL (S)-(+)-MANDELATE

Base Information

• Chemical Name: (+)-CIS-TRAMADOL (S)-(+)-MANDELATE
• CAS No.: 280565-80-2
• Molecular Formula: C₈H₈O₃*C₁₆H₂₅NO₂
• Molecular Weight: 415.53
• Mol file: 280565-80-2.mol

Synonyms:(+)-CIS-TRAMADOL (S)-(+)-MANDELATE;(S)-(+)-Mandelate

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Chemical Property of (+)-CIS-TRAMADOL (S)-(+)-MANDELATE

Chemical Property:

• PSA: 90.23000
• LogP: 3.43920

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-CIS-TRAMADOL (S)-(+)-MANDELATE

There total 25 articles about (+)-CIS-TRAMADOL (S)-(+)-MANDELATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

(S)-Mandelic acid (17199-29-0) + tramadol (2914-77-4,152538-36-8,181289-58-7,181289-59-8) → (+)-tramadol*(L)-(+)-mandelic acid (280565-80-2)

Guidance literature:

With seed of (+)-tramadol*(L)-mandelic acid; In ethyl acetate; at 25 - 70 ℃; for 7h;

DOI:10.1021/op0255276

Reference yield: 64.2%

(S)-Mandelic acid (17199-29-0) + tramadol (2914-77-4,152538-36-8,181289-58-7,181289-59-8) → (+)-tramadol*(L)-(+)-mandelic acid (280565-80-2) + C16H25NO2*C8H8O3 (280565-80-2)

Guidance literature:

With seed of (+)-tramadol*(L)-mandelic acid; In ethyl acetate; at 25 - 75 ℃; for 5.5h; Concentration;

DOI:10.1021/op0255276

Reference yield: 64.2%

(S)-Mandelic acid (17199-29-0) + tramadol (2914-77-4,152538-36-8,181289-58-7,181289-59-8) → (+)-tramadol*(L)-(+)-mandelic acid (280565-80-2) + C16H25NO2*C8H8O3 (280565-80-2)

Guidance literature:

With seed of (+)-tramadol*(L)-mandelic acid; In ethyl acetate; at 25 - 75 ℃; for 5.5h; Concentration;

DOI:10.1021/op0255276

upstream raw materials:

(R)-Mandelic Acid

cis-tramadol

(S)-Mandelic acid

tramadol

Downstream raw materials:

tramadol

(-)-tramadol

(-)-tramadol hydrochloride

Refernces

• 1、 Evans, Graham R.,Fernandez, Paloma Diaz,Henshilwood, James A.,Lloyd, Steve,Nicklin, Chris. "Development of highly efficient resolutions of racemic tramadol using mandelic acid". . p. 729 - 737. Retrieved 2013/09/06.