C₅₅H₈₁N₉O₈

Base Information

• Chemical Name: C₅₅H₈₁N₉O₈
• CAS No.: 1519003-78-1
• Molecular Formula: C₅₅H₈₁N₉O₈
• Molecular Weight: 996.304
• Mol file: 1519003-78-1.mol

Synonyms:C₅₅H₈₁N₉O₈

Chemical Property of C₅₅H₈₁N₉O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₅H₈₁N₉O₈

There total 18 articles about C₅₅H₈₁N₉O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-(2,5,8,11,14-pentaoxaheptadec-16-yn-1-yl)benzoyl)azetidin-2-one (1430096-70-0) + C33H52N8O (1519003-75-8) → C55H81N9O8 (1519003-78-1)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol; In tert-butyl alcohol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ml400370w

Reference yield:

8-Benzyl-1αH,5αH-nortropan-3-one Oxime (76272-34-9) → C55H81N9O8 (1519003-78-1)

Guidance literature:

Multi-step reaction with 12 steps

1: sodium; propan-1-ol / toluene / 12 h / Reflux; Inert atmosphere

2: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

3: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

4: sodium carbonate / water; dichloromethane / 0 - 20 °C / Inert atmosphere

5: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

6: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere

7: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere

8: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere

9: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 0 - 20 °C / Inert atmosphere

10: hydrogenchloride / methanol; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

11: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

12: 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol; copper(II) sulfate; sodium L-ascorbate / tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; propan-1-ol; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen; sodium; sodium tris(acetoxy)borohydride; sodium carbonate; benzotriazol-1-ol; copper(II) sulfate; acetic acid; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol; In tetrahydrofuran; 1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

DOI:10.1021/ml400370w

Reference yield:

8-benzyl-8-azabicyclo[3.2.1]octan-3-amine → C55H81N9O8 (1519003-78-1)

Guidance literature:

Multi-step reaction with 11 steps

1: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

3: sodium carbonate / water; dichloromethane / 0 - 20 °C / Inert atmosphere

4: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere

6: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere

7: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere

8: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 0 - 20 °C / Inert atmosphere

9: hydrogenchloride / methanol; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

10: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

11: 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol; copper(II) sulfate; sodium L-ascorbate / tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; benzotriazol-1-ol; copper(II) sulfate; acetic acid; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol; In tetrahydrofuran; 1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1021/ml400370w

upstream raw materials:

8-Benzyl-1αH,5αH-nortropan-3-one Oxime

exo-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester

C₂₀H₃₀N₄O

8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl-amine

Refernces