3-hydroxylphthalonitrile

Base Information

• Chemical Name: 3-hydroxylphthalonitrile
• CAS No.: 116039-49-7
• Molecular Formula: C₈H₄N₂O
• Molecular Weight: 144.133
• Mol file: 116039-49-7.mol

Synonyms:3-hydroxylphthalonitrile

Chemical Property of 3-hydroxylphthalonitrile

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

3-hydroxyphthalonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxylphthalonitrile

There total 2 articles about 3-hydroxylphthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-nitrobenzene-1,2-dicarbonitrile (51762-67-5) → 3-hydroxylphthalonitrile (116039-49-7)

Guidance literature:

3-nitrobenzene-1,2-dicarbonitrile; With potassium carbonate; sodium nitrite; In dimethyl sulfoxide; at 160 ℃; for 3h;

With hydrogenchloride; water; pH=3;

Reference yield:

2,2-diethyl-1,3-propanediol (115-76-4) + 3-nitrobenzene-1,2-dicarbonitrile (51762-67-5) → 3-hydroxylphthalonitrile (116039-49-7) + 3-(2',3'-dicyanophenoxy)-2,2-diethylpropan-1-ol + dicyanophenyl ether + 1,3-bis(2',3'-dicyanophenoxy)-2,2-diethylpropane

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; Title compound not separated from byproducts; 50 deg C; RT, 3 d;

DOI:10.1139/v96-035

Reference yield: 96.0%

3-hydroxylphthalonitrile (116039-49-7) → 3-hydroxyphthalic acid (601-97-8)

Guidance literature:

With water; potassium hydroxide; at 130 ℃; for 90h;

upstream raw materials:

2,2-diethyl-1,3-propanediol

3-nitrobenzene-1,2-dicarbonitrile

Downstream raw materials:

3-[1-(trimethylsilyl)ethoxy]-phthalonitrile

3-[3-(trimethylsilyl)propoxy]phthalonitrile

3-methoxybenzene-1,2-dicarbonitrile

3-(trimethylsilylmethoxy)-phthalonitrile

Refernces

• 1、 Liu, Xingjiang,Tian, HuiHui,Yang, Lei,Su, Yuanan,Guo, Man,Song, Xiangzhi. "An ESIPT-based fluorescent probe for sensitive and selective detection of Cys/Hcy over GSH with a red emission and a large Stokes shift". . p. 3209 - 3213. Retrieved 2017.
• 2、 -. "A recognition cysteine and homocysteine novel fluorescent probe synthesis and application of". Paragraph 0004; 0026-0027. . Retrieved 2018/04/21.
• 3、 -. "Synthesis and application of novel fluorescence probe for detecting hydrogen peroxide". Paragraph 0004; 0021. . Retrieved 2017/08/29.