Z-DL-ASPARAGINE

Base Information

• Chemical Name: Z-DL-ASPARAGINE
• CAS No.: 29880-22-6
• Molecular Formula: C12H14N2O5
• Molecular Weight: 266.254
• Hs Code.: 29350090
• Mol file: 29880-22-6.mol

Synonyms:Asparagine,N2-carboxy-, N2-benzyl ester, DL- (8CI);DL-Asparagine,N2-[(phenylmethoxy)carbonyl]-;N-Benzyloxycarbonyl-DL-asparagine;N-Carbobenzoxy-DL-asparagine;

Chemical Property of Z-DL-ASPARAGINE

Chemical Property:

• Melting Point: 165 °C
• Boiling Point: 580.6 °C at 760 mmHg
• PKA: 3.77±0.10(Predicted)
• Flash Point: 304.9 °C
• PSA: 118.72000
• Density: 1.355 g/cm³
• LogP: 1.33260
• Storage Temp.: Store at RT.
• Water Solubility.: almost transparency in hot Water

Purity/Quality:

98%,99%, ^*data from raw suppliers

N～2～-[(Benzyloxy)carbonyl]asparagine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N～2～-[(Benzyloxy)carbonyl]asparagine is used as an intermediate in the synthesis of amino acids and peptides related to arginine-vasopressin.

Technology Process of Z-DL-ASPARAGINE

There total 4 articles about Z-DL-ASPARAGINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.3%

ASPARAGINE (3130-87-8,28088-48-4,7006-34-0) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxy-carbonyl-DL-asparagine (29880-22-6)

Guidance literature:

With sodium carbonate; In acetone; at 0 - 20 ℃; pH=8 - 9; Large scale;

Reference yield: 85.0%

N-Benzyloxycarbonyl-D-asparagin-p-nitrobenzylester (3561-56-6,58578-32-8) → 2-Benzyloxycarbonylamino-succinamic acid (2304-96-3,4474-86-6,29880-22-6)

Guidance literature:

With sodium dithionite; sodium carbonate; In acetonitrile;

Reference yield:

ASPARAGINE (3130-87-8,28088-48-4,7006-34-0) → N-benzyloxy-carbonyl-DL-asparagine (29880-22-6)

Guidance literature:

With water; magnesium oxide; benzyl chloroformate;

upstream raw materials:

ASPARAGINE

benzyl chloroformate

N-Benzyloxycarbonyl-D-asparagin-p-nitrobenzylester

Downstream raw materials:

(R)-4-amino-2-(((benzyloxy)carbonyl)amino)-4-oxobutanoic acid

N-benzyloxycarbonyl-L-asparagine

[2-Carbamoyl-1-(2-chloro-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester

N-benzyloxycarbonyl-D,L-asparagine ethyl ester

Refernces

• 1、 -. "Preparation method of N-carbobenzoxy-3-amino-alanine tert-butyl ester". Paragraph 0012; 0014; 0016. . Retrieved 2019/04/10.