4,6-Diphenyl-2-pyridone

Base Information

• Chemical Name: 4,6-Diphenyl-2-pyridone
• CAS No.: 29261-44-7
• Molecular Formula: C17H13 N O
• Molecular Weight: 247.296
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90397234
• Nikkaji Number: J527.108H
• Wikidata: Q82198406
• Mol file: 29261-44-7.mol

Synonyms:4,6-diphenyl-2-pyridone;29261-44-7;4,6-diphenyl-1H-pyridin-2-one;4,6-diphenylpyridin-2-ol;4,6-Diphenylpyridin-2(1H)-one;4,6-Diphenyl-1,2-dihydropyridin-2-one;4,6-Diphenyl-pyridone;starbld0009929;4,6-diphenyl,2-pyridone;4.6-diphenyl-2-pyridone;4,6-diphenyl-2-pyridinone;2-pyridinol, 4,6-diphenyl-;SCHEMBL6756097;2-Hydroxy-4,6-diphenylpyridine;DTXSID90397234

Chemical Property of 4,6-Diphenyl-2-pyridone

Chemical Property:

• PSA: 33.12000
• LogP: 4.12120
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 247.099714038
• Heavy Atom Count: 19
• Complexity: 396

Purity/Quality:

99%min ^*data from raw suppliers

4,6-Diphenylpyridin-2(1H)-one(90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=O)NC(=C2)C3=CC=CC=C3

Technology Process of 4,6-Diphenyl-2-pyridone

There total 84 articles about 4,6-Diphenyl-2-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3-diphenyl-propen-3-one (614-47-1) + cyanoacetic acid amide (107-91-5) → 4,6-diphenyl-2-pyridone (29261-44-7)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 90 ℃; for 4h;

DOI:10.1021/jo025546d

Reference yield: 96.0%

4,6-diphenylpyridin-2-yl 4-methylbenzene-1-sulfonate → 4,6-diphenyl-2-pyridone (29261-44-7)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c7cc08039e

Reference yield: 92.0%

2-(1H-benzo[d][1,2,3]-triazol-1-yl)acetamide (69218-56-0) + 1,3-diphenyl-propen-3-one (614-47-1) → 4,6-diphenyl-2-pyridone (29261-44-7)

Guidance literature:

With sodium hydroxide; In ethanol; for 6h; Heating;

DOI:10.1021/jo970561h

upstream raw materials:

3-cyano-4,6-diphenyl-2-pyridone

2-oxo-4,6-diphenyl-1,2,3,4-tetrahydropyridine-3-carbonitrile

Benzoylacetonitrile

acetophenone

Downstream raw materials:

2,2-dimethyl-6-[(4,6-diphenyl-pyridin-2-yl)oxy]hexanonitrile

ethyl 6-[(4,6-diphenyl-pyridin-2-yl)oxy]hexanoate

6-[(4,6-diphenyl-pyridin-2-yl)oxy]hexanonitrile

ethyl 2-ethyl-2-methyl-6-[(4,6-diphenyl-2-pyridyl)oxy]hexanoate

Refernces

• 1、 Liu, Rui-Hua,Shen, Zhen-Yao,Wang, Cong,Loh, Teck-Peng,Hu, Xu-Hong. "Selective Dehydrogenative Acylation of Enamides with Aldehydes Leading to Valuable β-Ketoenamides". supporting information. p. 944 - 949. Retrieved 2020/02/15.
• 2、 Breuer, Natascha,Müller, Thomas J. J.. "Consecutive Alkynylation-Michael Addition-Cyclocondensation (AMAC) Multicomponent Syntheses of α-Pyrones and α-Pyridones". . p. 2741 - 2752. Retrieved 2018/06/08.