AC-DEVD-AFC

Base Information

• Chemical Name: AC-DEVD-AFC
• CAS No.: 201608-14-2
• Molecular Formula: C30H34 F3 N5 O13
• Molecular Weight: 729.621
• Mol file: 201608-14-2.mol

Synonyms:N-ACETYL-ASP-GLU-VAL-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;N-ACETYL-ASP-GLU-VAL-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN);N-ACETYL-ASP-GLU-VAL-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC;CASPASE 3 (APOPAIN) SUBSTRATE 1F, FLUOROGENIC;CASPASE-3 SUBSTRATE (AFC);CASPASE-3 SUBSTRATE VII, FLUOROGENIC;CASPASE-3 FLUOROGENIC SUBSTRATE;FLUOROGENIC CASPASE 3 SUBSTRATE AC-DEVD-AFC

Chemical Property of AC-DEVD-AFC

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1152.7 °C at 760 mmHg
• PKA: 4.09±0.10(Predicted)
• Flash Point: 650.9 °C
• PSA: 287.61000
• Density: 1.495 g/cm³
• LogP: 1.81620
• Storage Temp.: −20°C
• Solubility.: H2O: 1 mg/mL

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ac-DEVD-AFC ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: A fluorogenic substrate for caspase-3 Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 (CPP32) and related cysteine proteases, which emits a blue to green shift in fluorescence. It also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10. It is known that Ac-DEVD-AFC has a greater Stokes'' shift than Ac-DEVD-AMC once it has been cleaved. Since caspase-3 is an effector caspase, it is involved in the cleavage of many substrates which promote apoptosis. This indicator excites light at 400 nm and emits light at 505 nm. In addition, Ac-DEVD-AFC is modeled after Asp216 on caspase-3, the PARP cleavage site. Ac-DEVD-AFC is an essential indicator used to monitor the cellular effects of caspase-3.