tert-butyl 2-(benzylamino)-2-methylpropanoate

Base Information

• Chemical Name: tert-butyl 2-(benzylamino)-2-methylpropanoate
• CAS No.: 1355158-73-4
• Molecular Formula: C₁₅H₂₃NO₂
• Molecular Weight: 249.353
• Mol file: 1355158-73-4.mol

Synonyms:tert-butyl 2-(benzylamino)-2-methylpropanoate

Chemical Property of tert-butyl 2-(benzylamino)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 2-(benzylamino)-2-methylpropanoate

There total 2 articles about tert-butyl 2-(benzylamino)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl bromoisobutyrate (23877-12-5) + benzylamine (100-46-9) → tert-butyl 2-(benzylamino)-2-methylpropanoate (1355158-73-4)

Guidance literature:

With sodium hydrogencarbonate; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃;

Reference yield:

H-Aib-OtBu (4512-32-7) + benzyl bromide (100-39-0) → tert-butyl 2-(benzylamino)-2-methylpropanoate (1355158-73-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1002/open.202100216

Reference yield:

tert-butyl 2-(benzylamino)-2-methylpropanoate (1355158-73-4) + p-chlorphenylisocyanate (104-12-1) → 1-benzyl-3-(4-chlorophenyl)-5,5-dimethylimidazolidine-2,4-dione

Guidance literature:

tert-butyl 2-(benzylamino)-2-methylpropanoate; p-chlorphenylisocyanate; In acetone; at 20 ℃;

With hydrogenchloride; In water; acetonitrile; at 20 ℃; for 10h;

DOI:10.1002/open.202100216

upstream raw materials:

tert-butyl bromoisobutyrate

benzylamine

H-Aib-OtBu

benzyl bromide

Downstream raw materials:

H-Aib-OtBu

Refernces

• 1、 -. "5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS". Page/Page column 64; 77. . Retrieved 2012/02/01.