N'-aminopyridine-4-carboximidamide

Base Information

• Chemical Name: N'-aminopyridine-4-carboximidamide
• CAS No.: 89830-71-7
• Molecular Formula: C6H8 N4
• Molecular Weight: 136.156
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10409025
• Mol file: 89830-71-7.mol

Synonyms:N'-aminopyridine-4-carboximidamide;89830-71-7;4-pyridinecarboxyamidrazone;DTXSID10409025;SMBOKVZNCISDCP-UHFFFAOYSA-N;4-Pyridinecarboximidic acid hydrazide;AKOS010600751

Chemical Property of N'-aminopyridine-4-carboximidamide

Chemical Property:

• Boiling Point: 377.5oC at 760 mmHg
• Flash Point: 182.1oC
• PSA: 74.79000
• LogP: 1.06120
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 136.074896272
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

98% ^*data from raw suppliers

4-PYRIDINECARBOXIMIDIC ACID, HYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC=C1C(=NN)N

Technology Process of N'-aminopyridine-4-carboximidamide

There total 8 articles about N'-aminopyridine-4-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

pyridine-4-carbonitrile (100-48-1) → 3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine (57654-36-1) + pyridine-4-carboxyimidehydrazide (89830-71-7)

Guidance literature:

With hydrazine; In water; at 50 ℃; for 4h;

Reference yield: 96.0%

pyridine-4-carbonitrile (100-48-1) → pyridine-4-carboxyimidehydrazide (89830-71-7)

Guidance literature:

With hydrazine; In diethyl ether; ethanol; at 0 - 20 ℃;

DOI:10.1021/acs.jmedchem.7b00443

Reference yield: 89.0%

pyridine-4-carbonitrile (100-48-1) → pyridine-4-carboxylic acid amidrazone (89830-71-7)

Guidance literature:

pyridine-4-carbonitrile; With sodium methylate; In ethanol; at 25 ℃; for 3h; Large scale;

With hydrazine hydrate; In ethanol; tert-butyl methyl ether; at 0 - 10 ℃; for 12h; Large scale;

upstream raw materials:

pyridine-4-carbothioamide

pyridine-4-methylimine acid ethyl ester

pyridine-4-carbonitrile

Downstream raw materials:

1-(2-aminobenzoyl)-2-(isonicotinimidoyl)hydrazine

5,6-bis(4-bromophenyl)-3-(4-pyridyl)-1,2,4-triazine

5,6-bis(4-bromophenyl)-2,4'-bipyridine

Refernces

• 1、 -. "Synthesis method of topiroxostat". Paragraph 0038-0042. . Retrieved 2021/07/17.
• 2、 -. "PYRIDINIUM COMPOUNDS AND THEIR USE AS HERBICIDES". Page/Page column 64. . Retrieved 2020/08/28.