C₃₅H₃₉N₃O₆

Base Information

• Chemical Name: C₃₅H₃₉N₃O₆
• CAS No.: 1338053-58-9
• Molecular Formula: C₃₅H₃₉N₃O₆
• Molecular Weight: 597.711
• Mol file: 1338053-58-9.mol

Synonyms:C₃₅H₃₉N₃O₆

Chemical Property of C₃₅H₃₉N₃O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₃₉N₃O₆

There total 5 articles about C₃₅H₃₉N₃O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(9H-fluoren-9-yl)methyl (S)-1-isocyano-3-phenylpropan-2-ylcarbamate (1095037-88-9) + H-Asp-OMe (17812-32-7,65414-77-9,65414-78-0,89495-37-4) + isovaleraldehyde (590-86-3) → C35H39N3O6 (1338053-58-9)

Guidance literature:

H-Asp-OMe; isovaleraldehyde; In methanol; at 20 ℃; for 1h;

(9H-fluoren-9-yl)methyl (S)-1-isocyano-3-phenylpropan-2-ylcarbamate; In methanol; at 20 ℃; optical yield given as %de; diastereoselective reaction;

DOI:10.1016/j.tetlet.2011.08.090

Reference yield:

(9H-fluoren-9-yl)methyl (S)-1-formamido-3-phenylpropan-2-ylcarbamate (1095037-60-7) → C35H39N3O6 (1338053-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Burgess Reagent / dichloromethane / 60 °C

2.1: methanol / 1 h / 20 °C

2.2: 20 °C

With Burgess Reagent; In methanol; dichloromethane; 2.1: Ugi reaction / 2.2: Ugi reaction;

DOI:10.1016/j.tetlet.2011.08.090

Reference yield:

(1-azidocarbonylmethyl-2-phenyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (270575-68-3) → C35H39N3O6 (1338053-58-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene / 65 °C

2.1: dmap; formic acid / dichloromethane / -15 °C

3.1: Burgess Reagent / dichloromethane / 60 °C

4.1: methanol / 1 h / 20 °C

4.2: 20 °C

With dmap; formic acid; Burgess Reagent; In methanol; dichloromethane; toluene; 4.1: Ugi reaction / 4.2: Ugi reaction;

DOI:10.1016/j.tetlet.2011.08.090

upstream raw materials:

(9H-fluoren-9-yl)methyl (S)-1-isocyano-3-phenylpropan-2-ylcarbamate

H-Asp-OMe

isovaleraldehyde

(9H-fluoren-9-yl)methyl (S)-1-formamido-3-phenylpropan-2-ylcarbamate

Refernces