5-Chloro-2-iodopyrimidine

Base Information

• Chemical Name: 5-Chloro-2-iodopyrimidine
• CAS No.: 874676-81-0
• Molecular Formula: C4H2 Cl I N2
• Molecular Weight: 240.431
• Hs Code.: 2933599090
• Mol file: 874676-81-0.mol

Synonyms:5-chloro-2-iodopyrimidine

Chemical Property of 5-Chloro-2-iodopyrimidine

Chemical Property:

• Boiling Point: 316.6 °C at 760 mmHg
• PKA: -2.56±0.22(Predicted)
• Flash Point: 145.3 °C
• PSA: 25.78000
• Density: 2.187 g/cm³
• LogP: 1.73460
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Sensitive.: Light Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloro-2-iodopyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Useful Intermediate for organic synthesis and pharmaceutical.

Technology Process of 5-Chloro-2-iodopyrimidine

There total 1 articles about 5-Chloro-2-iodopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dichloropyrimidine (22536-67-0) → 5-chloro-2-iodopyrimidine (874676-81-0)

Guidance literature:

2,5-dichloropyrimidine; With hydrogen iodide; In water; at 0 ℃; for 4h;

With potassium carbonate; In water;

Reference yield: 87.0%

4-HYDROXYPIPERIDINE (5382-16-1) + 5-chloro-2-iodopyrimidine (874676-81-0) → 1-(5-chloropyrimidin-2-yl)piperidin-4-ol (1108164-37-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 82.0%

5-chloro-2-iodopyrimidine (874676-81-0) + methyl 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1-(tosyl)-1H-pyrrole-2-carboxylate (1221420-58-1) → methyl 4-(5-chloropyrimidin-2-yl)-1-(tosyl)-1H-pyrrole-2-carboxylate (1221420-59-2)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; toluene; at 100 ℃; for 3h;

upstream raw materials:

2,5-dichloropyrimidine

Downstream raw materials:

4-(1-(5-chloropyrimidin-2-yl)piperidin-4-yloxy)-1-(4-(methylsulfonyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carbonitrile

6-(hydroxymethyl)-5-(1-(5-chloropyrimidin-2-yl)piperidin-4-yloxy)-2-(4-(methylsulfonyl)phenyl)pyridazin-3(2H)-one

methyl 4-(5-chloropyrimidin-2-yl)-1-(tosyl)-1H-pyrrole-2-carboxylate

1-(5-chloropyrimidin-2-yl)piperidin-4-ol

Refernces

• 1、 -. "VIRAL POLYMERASE INHIBITORS". Page/Page column 55. . Retrieved 2010/11/26.