N^α-Fmoc-L-Asn-OPfp

Base Information

• Chemical Name: N^α-Fmoc-L-Asn-OPfp
• CAS No.: 797751-68-9
• Molecular Formula: C₂₅H₁₆F₅NO₆
• Molecular Weight: 521.397
• Mol file: 797751-68-9.mol

Synonyms:N^α-Fmoc-L-Asn-OPfp

Chemical Property of N^α-Fmoc-L-Asn-OPfp

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-Fmoc-L-Asn-OPfp

There total 1 articles about N^α-Fmoc-L-Asn-OPfp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-pentafluorophenyl L-aspartate (86061-01-0,200335-75-7) → Nα-Fmoc-L-Asn-OPfp (797751-68-9)

Guidance literature:

With trifluoroacetic acid; for 0.5h; Yield given;

DOI:10.1016/S0040-4039(00)97223-X

Reference yield:

Fmoc-Gly-OPfp (86060-85-7) + Nα-Fmoc-L-Asn-OPfp (797751-68-9) + Fmoc-Lys-OPfp → C34H55N11O18

Guidance literature:

Fmoc-Lys-OPfp; With pyrazolone orange; C₁₄H₁₂FeO₆^(1-)*Na⁽¹⁺⁾; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Combinatorial reaction / High throughput screening (HTS); Inert atmosphere; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide;

Fmoc-Gly-OPfp; N^α-Fmoc-L-Asn-OPfp; Fmoc-Lys-OPfp; Further stages;

DOI:10.1002/anie.200801616

Reference yield:

Fmoc-Gly-OPfp (86060-85-7) + N-α-fluorenylmethoxycarbonyl-L-tryptophan pentafluorophenyl ester (86069-87-6,136554-94-4) + Nα-Fmoc-L-Asn-OPfp (797751-68-9) + Fmoc-L-Glu-OPfp-OH → KKEEWWDDGKKEEWWDD

Guidance literature:

Multistep reaction;

DOI:10.1002/anie.200500261

upstream raw materials:

tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-pentafluorophenyl L-aspartate

Downstream raw materials:

Asp-Phe-NH₂

N^α-(Fluoren-9-ylmethoxycarbonyl)-L-aspartic 4-Acid Chloride 1-pentafluorophenyl Ester

Fmoc-Asn(Ac3GlcNAcβ1-N-)-O-Pfp

Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-NH₂

Refernces