BOC-HIS(3-BOM)-OME HCL

Base Information

• Chemical Name: BOC-HIS(3-BOM)-OME HCL
• CAS No.: 83468-80-8
• Molecular Formula: C₂₀H₂₇N₃O₅*ClH
• Molecular Weight: 425.912
• Mol file: 83468-80-8.mol

Synonyms:BOC-N-P-BENZYLOXYMETHYL-L-HISTIDINE METHYL ESTER HYDROCHLORIDE;BOC-HIS(3-BOM)-OME HCL;BOC-HIS(BOM)-OME HCL;BOC-HIS(PI-BOM)-OME HCL;BOC-HIS(P-BOM)-OME HCL;BOC-HISTIDINE(3-BOM)-OME HCL;N-ALPHA-T-BUTOXYCARBONYL-N-PI-BENZYLOXYMETHYL-L-HISTIDINE ALPHA-METHYL ESTER HYDROCHLORIDE;Boc-His(Bom)-Ome hydrochloride

Chemical Property of BOC-HIS(3-BOM)-OME HCL

Chemical Property:

• PSA: 91.68000
• LogP: 3.85910
• Storage Temp.: -15°C

Purity/Quality:

98.5% ^*data from raw suppliers

Boc-N-p-benzyloxymethyl-L-histidine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BOC-HIS(3-BOM)-OME HCL

There total 1 articles about BOC-HIS(3-BOM)-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

Benzyloxymethyl chloride (3587-60-8) + 4-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-imidazole-1-carboxylic acid tert-butyl ester (20898-43-5,133467-03-5,165062-56-6) → N(α)-t-butoxycarbonyl-N(?)-benzyloxymethyl-L-histidine methyl ester hydrochloride (83468-80-8)

Guidance literature:

In dichloromethane;

Reference yield:

N-[(1,1-dimethylethoxy)carbonyl]-3-[(phenylmethoxy)methyl]-L-histidine (79950-65-5,99310-01-7) + N(α)-t-butoxycarbonyl-N(?)-benzyloxymethyl-L-histidine methyl ester hydrochloride (83468-80-8) → N(α)-t-butoxycarbonyl-N(?)-benzyloxymethyl-L-histidyl-N(?)-benzyloxymethyl-L-histidine methyl ester (83468-95-5)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; Yield given. Multistep reaction; 1.) 0.5 h, 2.) DMF;

upstream raw materials:

Benzyloxymethyl chloride

4-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-imidazole-1-carboxylic acid tert-butyl ester

Downstream raw materials:

N(α)-t-butoxycarbonyl-N(?)-benzyloxymethyl-L-histidyl-N(?)-benzyloxymethyl-L-histidine methyl ester

Refernces