Phenol, 2-amino-5-fluoro-4-methyl- (9CI)

Base Information

• Chemical Name: Phenol, 2-amino-5-fluoro-4-methyl- (9CI)
• CAS No.: 83341-37-1
• Molecular Formula: C7H8 F N O
• Molecular Weight: 141.145
• Mol file: 83341-37-1.mol

Synonyms:Phenol, 2-amino-5-fluoro-4-methyl- (9CI)

Chemical Property of Phenol, 2-amino-5-fluoro-4-methyl- (9CI)

Chemical Property:

• Melting Point: 130 - 132 °C
• PSA: 46.25000
• LogP: 2.00310

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-fluoro-4-methylphenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 2-amino-5-fluoro-4-methyl- (9CI)

There total 3 articles about Phenol, 2-amino-5-fluoro-4-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

→ 2-amino-5-fluoro-4-methylphenol (83341-37-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 4h;

Reference yield: 88.0%

5-fluoro-4-methyl-2-nitrophenol (83341-28-0) → 2-amino-5-fluoro-4-methylphenol (83341-37-1)

Guidance literature:

With hydrogen; at 25 ℃; under 75007.5 Torr;

Reference yield:

3-fluoro-4-methyl phenol (452-78-8) → 2-amino-5-fluoro-4-methylphenol (83341-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 99 percent HNO₃ / acetic acid / 4 h / Ambient temperature

2: 27 percent / H₂ / Raney-Ni / ethanol / 50 °C / 37503 Torr

With hydrogen; nitric acid; nickel; In ethanol; acetic acid;

upstream raw materials:

5-fluoro-4-methyl-2-nitrophenol

3-fluoro-4-methyl phenol

Downstream raw materials:

1,1-dimethylethyl 4-[(4-fluoro-2-hydroxy-5-methylphenyl)amino]-1-piperidinecarboxylate

2-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-5-fluoro-4-methylphenol

Refernces

• 1、 -. "COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE". Page/Page column 74. . Retrieved 2009/04/25.