4-Acetamidopicolinic acid

Base Information

• Chemical Name: 4-Acetamidopicolinic acid
• CAS No.: 84487-16-1
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.163
• Hs Code.: 29333990
• DSSTox Substance ID: DTXSID30516043
• Wikidata: Q82377261
• Mol file: 84487-16-1.mol

Synonyms:4-acetamidopicolinic acid;84487-16-1;4-ACETAMIDOPYRIDINE-2-CARBOXYLIC ACID;4-(Acetylamino)pyridine-2-Carboxylic Acid;4-Acetamidopicolinicacid;4-Acetamido-2-pyridinecarboxylic acid;SCHEMBL5906610;DTXSID30516043;MFCD09835092;AKOS012962550;AB53276;AS-58647;CS-0092045;F81456;EN300-3024029

Chemical Property of 4-Acetamidopicolinic acid

Chemical Property:

• PSA: 79.29000
• LogP: 0.81120
• Storage Temp.: 2-8°C
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 180.05349212
• Heavy Atom Count: 13
• Complexity: 217

Purity/Quality:

98%min ^*data from raw suppliers

4-Acetamidopyridine-2-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 36/37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC(=NC=C1)C(=O)O

Technology Process of 4-Acetamidopicolinic acid

There total 3 articles about 4-Acetamidopicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-acetylamino-2-methylpyridine (18085-47-7) → 4-acetylaminopyridine-2-carboxylic acid (84487-16-1)

Guidance literature:

With potassium permanganate; at 75 ℃; for 10h;

Reference yield:

3-methyl-4-pyridinamine (18437-58-6) → 4-acetylaminopyridine-2-carboxylic acid (84487-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / triethylamine / acetone / 48 h / Heating

2: aq. KMnO₄ / 10 h / 75 °C

With potassium permanganate; triethylamine; In acetone;

Reference yield:

→ 4-acetylaminopyridine-2-carboxylic acid (84487-16-1)

Guidance literature:

upstream raw materials:

4-acetylamino-2-methylpyridine

3-methyl-4-pyridinamine

Downstream raw materials:

4-aminopyridine-2-carboxylic acid

Refernces

• 1、 Deady, Leslie W.,Korytsky, Olga L.,Rowe, Jeffrey E.. "Substituent Effects on the Isomer Ratios in the Rearrangement of Some 2- and 4-Nitraminopyridines". . p. 2025 - 2034. Retrieved 2007/10/02.