H-DL-PHE-OTBU HCL

Base Information

• Chemical Name: H-DL-PHE-OTBU HCL
• CAS No.: 75898-47-4
• Molecular Formula: C₁₃H₂₀NO₂*Cl
• Molecular Weight: 257.76
• Mol file: 75898-47-4.mol

Synonyms:DL-Phenylalanine,1,1-dimethylethyl ester, hydrochloride; DL-Phenylalanine tert-butyl ester hydrochloride

Chemical Property of H-DL-PHE-OTBU HCL

Chemical Property:

• PSA: 52.32000
• LogP: 3.40040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

H-DL-Phe-OtBu.HCl 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36-52
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-DL-PHE-OTBU HCL

There total 10 articles about H-DL-PHE-OTBU HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + isobutene (115-11-7,15220-85-6) → L-phenylalanine tert-butyl ester hydrochloride (15100-75-1,75898-47-4)

Guidance literature:

With sulfuric acid; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)91366-3

Reference yield:

phenylalanine tert-butyl ester hydrochloride (75898-47-4) → L-phenylalanine tert-butyl ester hydrochloride (15100-75-1,75898-47-4) + tert-butyl (2R)-2-amino-3-phenyl-propanoate hydrochloride (3403-25-6,75898-47-4)

Guidance literature:

With chiral stationary phase including isopropyl-functionalized CF₆; In methanol; acetic acid; triethylamine; acetonitrile; at 20 ℃; Purification / work up;

Reference yield:

phenylalanine tert-butyl ester hydrochloride (75898-47-4) → L-phenylalanine tert-butyl ester hydrochloride (15100-75-1,75898-47-4) + tert-butyl (2R)-2-amino-3-phenyl-propanoate hydrochloride (3403-25-6,75898-47-4)

Guidance literature:

With chiral stationary phase including isopropyl-functionalized CF₆; In methanol; acetic acid; triethylamine; acetonitrile; at 20 ℃; Purification / work up;

upstream raw materials:

L-phenylalanine

isobutene

tert-butyl 2-((diphenylmethylene)amino)-3-phenylpropanoate

benzyl bromide

Downstream raw materials:

biliverdin-IXα bis<(S)-phenylalanine t-butyl ester>

N-(L-phenylalanine tert-butyl ester)-3β-acetyl-11-oxo-olean-12-en-18β-H-30-amide

t-butyl (R)-N-(diphenylmethylene)phenylalaninate

(S)-tert-butyl N-(diphenylmethylidene)phenylalanine

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS". Page/Page column 45-49; 60. . Retrieved 2010/12/31.
• 2、 Thorsen, M.,Andersen, T. P.,Pedersen, U.,Yde, B.,Lawesson, S.-O.,Hansen. H. F.. "STUDIES ON AMINO ACIDS AND PEPTIDES X. HPLC-MEDIATED TEST OF 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE (LAWESSONS'S REAGENT) AS A RACEMIZATIONFREE COUPLING REAGENT IN PEPTIDE SYNTHESIS". . p. 5633 - 5636. Retrieved 2007/10/02.