trans-4-(Trifluoromethyl)cyclohexanol

Base Information

• Chemical Name: trans-4-(Trifluoromethyl)cyclohexanol
• CAS No.: 75091-93-9
• Molecular Formula: C₇H₁₁F₃O
• Molecular Weight: 168.159
• Hs Code.: 2906190090
• Mol file: 75091-93-9.mol

Synonyms:trans-4-(Trifluoromethyl)cyclohexanol

Chemical Property of trans-4-(Trifluoromethyl)cyclohexanol

Chemical Property:

• Boiling Point: 160.4±35.0 °C(Predicted)
• PKA: 14.88±0.40(Predicted)
• PSA: 20.23000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 2.09980
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

trans-4-(Trifluoromethyl)cyclohexanol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-4-(Trifluoromethyl)cyclohexanol

There total 6 articles about trans-4-(Trifluoromethyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-hydroxybenzotrifluoride (402-45-9) → 4-(trifluoromethyl)cyclohexan-1-ol (75091-92-8,75091-93-9,30129-18-1)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide; for 16h; under 2585.81 Torr;

Reference yield: 28.0%

4-(trifluoromethyl)cyclohexan-1-one (75091-99-5) → 4-(trifluoromethyl)cyclohexan-1-ol (75091-92-8,75091-93-9,30129-18-1)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 ℃; for 0.5h; Inert atmosphere;

Reference yield:

trifluoromethylcyclohexane (401-75-2) → 3-(trifluoromethyl)cyclohexan-1-ol (454-63-7) + 4-(trifluoromethyl)cyclohexan-1-ol (75091-92-8,75091-93-9,30129-18-1) + 3-(trifluoromethyl)cyclohexanone (585-36-4) + 4-(trifluoromethyl)cyclohexan-1-one (75091-99-5)

Guidance literature:

With 2-Picolinic acid; tert.-butylhydroperoxide; ferric nitrate; In pyridine; acetic acid; at 25 ℃; for 16h; Further Variations:; Reagents; Product distribution;

DOI:10.1016/S0040-4020(02)00255-7

upstream raw materials:

4-hydroxybenzotrifluoride

Trifluoro-acetic acid 4-trifluoromethyl-cyclohexyl ester

trifluoromethylcyclohexane

4-(trifluoromethyl)cyclohexan-1-one

Downstream raw materials:

4-(trifluoromethyl)cyclohexan-1-one

trans-4-trifluoromethylcyclohexyl trans-4-pentylcyclohexanecarboxylate

7,7,7-Trifluormenthan-8-ol

4-trifluoromethylcyclohexanone oxime

Refernces

• 1、 Zhang, Xue,Ling, Liang,Luo, Meiming,Zeng, Xiaoming. "Accessing Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles: Preferential Hydrogen Addition to the Substitution Sites for Dearomatization". supporting information. p. 16785 - 16789. Retrieved 2019/11/11.
• 2、 -. "1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS". Paragraph 0837; 0838; 0839. . Retrieved 2016/09/22.