5'-O-[[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]-2'-C-methylcytidine

Base Information

• Chemical Name: 5'-O-[[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]-2'-C-methylcytidine
• CAS No.: 946511-63-3
• Molecular Formula: C₂₂H₃₁N₄O₉P
• Molecular Weight: 526.483
• Mol file: 946511-63-3.mol

Synonyms:5'-O-[[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]-2'-C-methylcytidine

Chemical Property of 5'-O-[[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]-2'-C-methylcytidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5'-O-[[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]-2'-C-methylcytidine

There total 1 articles about 5'-O-[[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]-2'-C-methylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 2'-C-methylcytidine (20724-73-6,115494-60-5) → 5'-O-[[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]-2'-C-methylcytidine (946511-63-3)

Guidance literature:

2'-C-methylcytidine; With tert-butylmagnesium chloride; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

phenyl(isopropoxy-L-alaninyl) phosphorochloridate; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm900447q

upstream raw materials:

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

2'-C-methylcytidine

Refernces