Multi-step reaction with 6 steps
1.1: chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; pyridine / Reflux; Inert atmosphere
1.2: 4 h / 25 °C / Inert atmosphere
2.1: ammonia / methanol / 25 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere
4.1: phosphorous acid trimethyl ester / 6 h / 120 °C / Inert atmosphere
5.1: hydrogen; 10% Pd/C / methanol / 5 h / 25 °C / Inert atmosphere
6.1: 1-methyl-1H-imidazole / tetrahydrofuran / 48 h / 25 °C / Inert atmosphere
With
pyridine; 1-methyl-1H-imidazole; chloro-trimethyl-silane; 10% Pd/C; ammonia; hydrogen; 1,1,1,3,3,3-hexamethyl-disilazane; phosphorous acid trimethyl ester;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
1.2: |Vorbrueggen Nucleoside Synthesis;
DOI:10.1021/jo500659e