diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate

Base Information

• Chemical Name: diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate
• CAS No.: 1567836-16-1
• Molecular Formula: C₃₂H₃₄N₂O₁₀S₂
• Molecular Weight: 670.761
• Mol file: 1567836-16-1.mol

Synonyms:diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate

Chemical Property of diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate

There total 4 articles about diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-diaminonaphthalene (2243-61-0) → diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate (1567836-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / toluene / 2 h / 100 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; potassium carbonate; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm5000529

Reference yield:

1-Nitronaphthalene (86-57-7) → diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate (1567836-16-1)

Guidance literature:

Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; potassium hydroxide / ethanol; methanol / 2 h / 50 - 60 °C

2: hydrogen; palladium on activated charcoal / tetrahydrofuran / 4 h / 20 °C

3: pyridine / toluene / 2 h / 100 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; palladium on activated charcoal; hydroxylamine hydrochloride; hydrogen; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm5000529

Reference yield:

1-amino-4-nitronaphthalene (776-34-1) → diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate (1567836-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium on activated charcoal / tetrahydrofuran / 4 h / 20 °C

2: pyridine / toluene / 2 h / 100 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; palladium on activated charcoal; hydrogen; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm5000529

upstream raw materials:

1,4-diaminonaphthalene

1-amino-4-nitronaphthalene

1-Nitronaphthalene

4-methoxy-phenyl-sulphonyl chloride

Downstream raw materials:

2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid

Refernces

• 1、 -. "Keap1-Nrf2 PPI inhibitor prodrug and preparation method and application". . . Retrieved 2021/02/06.
• 2、 Jain, Atul D.,Potteti, Haranatha,Richardson, Benjamin G.,Kingsley, Laura,Luciano, Julia P.,Ryuzoji, Aya F.,Lee, Hyun,Krunic, Aleksej,Mesecar, Andrew D.,Reddy, Sekhar P.,Moore, Terry W.. "Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators". . p. 252 - 268. Retrieved 2015/09/21.