H-D-Glu-OBzl

Base Information

• Chemical Name: H-D-Glu-OBzl
• CAS No.: 79338-14-0
• Molecular Formula: C12H15 N O4
• Molecular Weight: 237.255
• Mol file: 79338-14-0.mol

Synonyms:a-Benzyl D-glutamate

Chemical Property of H-D-Glu-OBzl

Chemical Property:

• Vapor Pressure: 1.15E-07mmHg at 25°C
• Melting Point: 154 °C
• Refractive Index: -28 ° (C=1, 1mol/L HCl)
• Boiling Point: 416oC at 760 mmHg
• PKA: 4.21±0.10(Predicted)
• Flash Point: 205.4oC
• Density: 1.245g/cm3
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4R)-4-Amino-5-oxo-5-phenylmethoxypentanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-D-Glu-OBzl

There total 6 articles about H-D-Glu-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-glutamic acid dibenzyl ester (47376-46-5) → D-glutamic acid 1-benzyl ester (79338-14-0)

Guidance literature:

With hydrogen iodide; acetic acid;

DOI:10.1021/ja01114a528

Reference yield:

D-Glutamic acid (6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → D-glutamic acid 1-benzyl ester (79338-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl

2: aqueous HI; acetic acid

With hydrogenchloride; hydrogen iodide; acetic acid;

DOI:10.1021/ja01114a528

Reference yield:

C2HF3O2*C16H23NO4 → D-glutamic acid 1-benzyl ester (79338-14-0)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 10 - 20 ℃;

DOI:10.1021/jm101535e

upstream raw materials:

D-glutamic acid dibenzyl ester

D-Glutamic acid

(R)-1-benzyl 5-tert-butyl 2-((tert-butoxycarbonyl)amino)pentanedioate

(tert-butoxy)carbonyl-D-glutamic acid 5-tert-butyl ester

Downstream raw materials:

α-benzyl caprylyl-D-glutamate

α-benzyl stearoyl-D-glutamate

(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanoic acid

(5R)-tribenzyl 1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

Refernces