montelukast isopropylamine salt

Base Information

• Chemical Name: montelukast isopropylamine salt
• CAS No.: 918972-53-9
• Molecular Formula: C₃H₉N*C₃₅H₃₆ClNO₃S
• Molecular Weight: 645.306
• Mol file: 918972-53-9.mol

Synonyms:montelukast isopropylamine salt

Chemical Property of montelukast isopropylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of montelukast isopropylamine salt

There total 3 articles about montelukast isopropylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ montelukast isopropylamine salt (918972-53-9)

Guidance literature:

Reference yield:

isopropylamine (75-31-0) + Montelukast sodium (151767-02-1) → montelukast isopropylamine salt (918972-53-9)

Guidance literature:

Montelukast sodium; With tartaric acid; In water; toluene; Inert atmosphere; Darkness;

isopropylamine; In n-heptane; toluene; for 2h; Product distribution / selectivity; Inert atmosphere; Darkness;

Reference yield:

2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol (880769-28-8) + isopropylamine (75-31-0) + 1-(sulfanylmethyl)cyclopropaneacetic acid (162515-68-6) → montelukast isopropylamine salt (918972-53-9)

Guidance literature:

2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol; With caesium carbonate; In N,N-dimethyl-formamide; at 33 - 35 ℃; for 0.0833333 - 0.25h;

1-(sulfanylmethyl)cyclopropaneacetic acid; In N,N-dimethyl-formamide; at 33 - 37 ℃; for 4.5 - 5.5h;

isopropylamine; With water; sodium chloride; more than 3 stages;

upstream raw materials:

2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol

isopropylamine

1-(sulfanylmethyl)cyclopropaneacetic acid

Montelukast sodium

Downstream raw materials:

1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid cyclohexylamine salt

1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt

Montelukast sodium

montelukast

Refernces

• 1、 -. "SPECIFIC IMPURITIES OF MONTELUKAST". Page/Page column 21-22. . Retrieved 2009/10/22.