FMOC-ASP-OME

Base Information

• Chemical Name: FMOC-ASP-OME
• CAS No.: 145038-52-4
• Molecular Formula: C₂₀H₁₉NO₆
• Molecular Weight: 369.374
• Hs Code.: 2924299090
• Mol file: 145038-52-4.mol

Synonyms:N-9-Fluorenylmethoxycarbonylasparticacid a-methyl ester;(3S)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methoxy-4-oxo-butanoic acid;FMOC-ASP-OME;Fmoc-L-aspartic acid alpha methyl ester;

Chemical Property of FMOC-ASP-OME

Chemical Property:

• Refractive Index: 1.596
• Boiling Point: 609.7 °C at 760 mmHg
• PKA: 4.05±0.19(Predicted)
• Flash Point: 322.5 °C
• PSA: 101.93000
• Density: 1.322 g/cm³
• LogP: 2.93230
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-Asp-OMe ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-ASP-OME

There total 7 articles about FMOC-ASP-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-tert-butyl 1-methyl 2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanedioate → 3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-methoxy-4-oxobutanoic acid (1227281-44-8,145038-52-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 97.0%

4-(tert-butyl) 1-methyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-aspartate (172846-53-6) → 3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid (145038-52-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.jorganchem.2019.121096

Reference yield: 75.0%

Fmoc-Asp(OAll)-OMe → 3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid (145038-52-4)

Guidance literature:

With dimethylamine borane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 20 ℃;

DOI:10.1039/a906025a

upstream raw materials:

Fmoc-(tBu)Asp-OH

4-(tert-butyl) 1-methyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-aspartate

α-methyl γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)aspartate

N-alpha-(9-fluorenylmethyloxycarbonyl)-D-aspartic acid beta-allyl ester

Refernces

• 1、 Daubit, Isabelle Marie,Wolf, Jonas,Metzler-Nolte, Nils. "Rhodium(I) and Iridium(I) N-Heterocyclic carbene complexes of imidazolium functionalized amino acids and peptides". . . Retrieved 2020/01/13.
• 2、 -. "HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANTIVIRAL DRUGS". . . Retrieved 2013/12/03.