2-fluoro-3-isobutoxybenzonitrile

Base Information

• Chemical Name: 2-fluoro-3-isobutoxybenzonitrile
• CAS No.: 1204182-09-1
• Molecular Formula: C₁₁H₁₂FNO
• Molecular Weight: 193.221
• Mol file: 1204182-09-1.mol

Synonyms:2-fluoro-3-isobutoxybenzonitrile

Chemical Property of 2-fluoro-3-isobutoxybenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-3-isobutoxybenzonitrile

There total 1 articles about 2-fluoro-3-isobutoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Isobutyl bromide (78-77-3) + 2-fluoro-3-hydroxybenzonitrile (1000339-24-1) → 2-fluoro-3-isobutoxybenzonitrile (1204182-09-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃;

Reference yield:

2-fluoro-3-isobutoxybenzonitrile (1204182-09-1) → C11H13FO2 (1204176-30-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2012.05.098

Reference yield:

2-fluoro-3-isobutoxybenzonitrile (1204182-09-1) → (R)-tert-butyl 1-(2-formyl-6-isobutoxyphenyl)piperidin-3-ylcarbamate (1204176-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / toluene / 0 - 20 °C

2: potassium carbonate / acetonitrile / Reflux

With diisobutylaluminium hydride; potassium carbonate; In toluene; acetonitrile;

DOI:10.1016/j.bmcl.2012.05.098

upstream raw materials:

Isobutyl bromide

2-fluoro-3-hydroxybenzonitrile

Downstream raw materials:

C₁₁H₁₃FO₂

(R)-tert-butyl 1-(2-formyl-6-isobutoxyphenyl)piperidin-3-ylcarbamate

(R,Z)-tert-butyl 1-(2-((2,4-dioxothiazolidin-5-ylidene)methyl)-6-isobutoxyphenyl)piperidin-3-ylcarbamate

Refernces

• 1、 -. "CHEMICAL COMPOUNDS 251". Page/Page column 171. . Retrieved 2011/10/02.