1,3,5-tricyclopropylbenzene

Base Information

• Chemical Name: 1,3,5-tricyclopropylbenzene
• CAS No.: 40735-09-9
• Molecular Formula: C₁₅H₁₈
• Molecular Weight: 198.308
• Mol file: 40735-09-9.mol

Synonyms:1,3,5-tricyclopropylbenzene

Chemical Property of 1,3,5-tricyclopropylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,5-tricyclopropylbenzene

There total 8 articles about 1,3,5-tricyclopropylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Cyclopropylacetylene (6746-94-7) → 1,3,5-tricyclopropylbenzene (40735-09-9)

Guidance literature:

With C₂₇H₄₀Cl₂FeN₄; sodium triethylborohydride; In toluene; at 20 ℃; for 16h; regioselective reaction;

DOI:10.1021/acscatal.1c00978

Reference yield:

Cyclopropylacetylene (6746-94-7) → 1,3,5-tricyclopropylbenzene (40735-09-9) + 1,2,4-tricyclopropylbenzene (41009-68-1)

Guidance literature:

diethylaluminium chloride; cobalt acetylacetonate; 1,2-bis-(diphenylphosphino)ethane; In benzene; at 60 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1007/BF00962138

Reference yield:

1,3,5-Tris(2,2-dichlorcyclopropyl)benzol (41009-81-8) → 1,3,5-tricyclopropylbenzene (40735-09-9)

Guidance literature:

With sodium methylate; In diethyl ether;

upstream raw materials:

1,3,5-tris(3'-bromopropyl)benzene

1,3,5-Tris(2,2-dichlorcyclopropyl)benzol

Cyclopropylacetylene

1,3,5-tris(3-hydroxypropyl)benzene

Downstream raw materials:

2,4,6-Tricyclopropylanilin (2-Amino-1,3,5-tricyclopropylbenzol)

2,4-Dibrom-1,3,5-tricyclopropylbenzol

2,4,6-Tricyclopropylbenzoesaeure

1,3,5-Tricyclopropyl-2,4-dinitrobenzol

Refernces

• 1、 Doll, Julianna S.,Eichelmann, Robert,Hertwig, Leif E.,Bender, Thilo,Kohler, Vincenz J.,Bill, Eckhard,Wadepohl, Hubert,Ro?ca, Drago?-Adrian. "Iron-catalyzed trimerization of terminal alkynes enabled by pyrimidinediimine ligands: A regioselective method for the synthesis of 1,3,5-substituted arenes". . p. 5593 - 5600. Retrieved 2021/05/31.
• 2、 Brenna, Davide,Villa, Matteo,Gieshoff, Tim N.,Fischer, Fabian,Hapke, Marko,Jacobi von Wangelin, Axel. "Iron-Catalyzed Cyclotrimerization of Terminal Alkynes by Dual Catalyst Activation in the Absence of Reductants". supporting information. p. 8451 - 8454. Retrieved 2017/07/11.