FMOC-D-ASP(OBZL)-OH

Base Information

• Chemical Name: FMOC-D-ASP(OBZL)-OH
• CAS No.: 150009-58-8
• Molecular Formula: C26H23 N O6
• Molecular Weight: 445.46
• Mol file: 150009-58-8.mol

Synonyms:FMOC-D-ASPARTIC ACID BETA-BENZYL ESTER;FMOC-D-ASPARTIC ACID(OBZL)-OH;FMOC-D-ASP(OBZL)-OH;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-ASPARTIC ACID BETA-BENZYL ESTER

Chemical Property of FMOC-D-ASP(OBZL)-OH

Chemical Property:

• Boiling Point: 687.2±55.0 °C(Predicted)
• PKA: 3.54±0.23(Predicted)
• PSA: 101.93000
• Density: 1.310±0.06 g/cm3(Predicted)
• LogP: 4.50270
• Storage Temp.: Store at RT.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-d-asp(obzl)-oh ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fmoc-d-asp(obzl)-oh is a useful intermediate for organic synthesis.

Technology Process of FMOC-D-ASP(OBZL)-OH

There total 8 articles about FMOC-D-ASP(OBZL)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid (2177-63-1,25248-99-1) → 9-fluorenylmethoxycarbonyl-O-benzyl-L-aspartic acid (150009-58-8,86060-84-6)

Guidance literature:

DOI:10.1055/s-1983-30327

Reference yield: 36.0%

N-(9-fluorenyl)methoxycarbonyl-aspartic anhydride (145038-47-7) + benzyl alcohol (100-51-6,185532-71-2) → 9-fluorenylmethoxycarbonyl-O-benzyl-L-aspartic acid (150009-58-8,86060-84-6)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃;

DOI:10.1039/d0cc07404g

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + D-aspartic acid β-benzyl ester (2177-63-1,63228-51-3,13188-89-1,25248-99-1) → Fmoc-D-Asp(OBn)-OH (150009-58-8)

Guidance literature:

In 1,4-dioxane; sodium carbonate;

upstream raw materials:

(S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid

(fluorenylmethoxy)carbonyl chloride

toluene-4-sulfonic acid

aspartic Acid

Downstream raw materials:

Boc-Ala-Asp-(OBzl)-Leu-Ala-Val-NH-CH₃

Fmoc-Asp(OBn)-Ala-OH

Fmoc-Asp(Bn)-Leu-OH

Refernces

• 1、 Mik, Václav,Mi?ková, Zuzana,Dole?al, Karel,Frébort, Ivo,Pospí?il, Tomá?. "Activity of (+)-Discadenine as a Plant Cytokinin". . p. 2136 - 2140. Retrieved 2017.
• 2、 Boyer,Stanchev,Fairbanks,Davis. "Ready protease-catalyzed synthesis of carbohydrate-amino acid conjugates.". . p. 1908 - 1909. Retrieved 2007/10/03.