Boc-D-Tyr(tBu)-OH

Base Information

• Chemical Name: Boc-D-Tyr(tBu)-OH
• CAS No.: 507276-74-6
• Molecular Formula: C18H27NO5
• Molecular Weight: 337.416
• Hs Code.: 2924299090
• Mol file: 507276-74-6.mol

Synonyms:Z-T-BUTYL-L-SERINE T-BUTYL ESTER;Z-O-T-BUTYL-L-SERINE T-BUTYL ESTER;Z-T-BUTYL-L-SERINE T-BUTYLESTER LIQUID;N-Carbobenzoxy-O-tert.-butyl-L-serin-tert.-butylester;

Chemical Property of Boc-D-Tyr(tBu)-OH

Chemical Property:

• Boiling Point: 484.0±40.0 °C(Predicted)
• PKA: 3.00±0.10(Predicted)
• PSA: 84.86000
• Density: 1.116±0.06 g/cm3(Predicted)
• LogP: 3.77520

Purity/Quality:

≥98%, ^*data from raw suppliers

Boc-O-tert-butyl-D-tyrosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-D-Tyr(tBu)-OH

There total 1 articles about Boc-D-Tyr(tBu)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + D-Tyr(Bu-t)-OH (186698-58-8) → Boc-D-Tyr(t-Bu)-OH (507276-74-6)

Guidance literature:

With sodium hydroxide; In water; tert-butyl alcohol; at 20 ℃; for 16h;

Reference yield: 91.0%

Boc-D-Tyr(t-Bu)-OH (507276-74-6) + methyl iodide (74-88-4) → (R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid (1246843-12-8)

Guidance literature:

Boc-D-Tyr(t-Bu)-OH; methyl iodide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With citric acid; In water; pH=3; Inert atmosphere;

DOI:10.1021/ol101801u

Reference yield: 78.0%

ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) + Boc-D-Tyr(t-Bu)-OH (507276-74-6) → C35H43FN4O7

Guidance literature:

Boc-D-Tyr(t-Bu)-OH; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime; In dichloromethane; at 0 ℃; for 0.0833333h;

ciprofloxacin; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/acs.bioconjchem.6b00057

upstream raw materials:

di-tert-butyl dicarbonate

D-Tyr(Bu-t)-OH

Downstream raw materials:

[1-(4-tert-butoxy-benzyl)-3-diazo-2-oxo-propyl]-carbamic acid tert-butylester

Refernces