D-Norleucine methyl ester hydrochloride

Base Information

• Chemical Name: D-Norleucine methyl ester hydrochloride
• CAS No.: 60687-33-4
• Molecular Formula: C₇H₁₅NO₂*ClH
• Molecular Weight: 181.663
• Hs Code.: 2922498590
• Mol file: 60687-33-4.mol

Synonyms:D-Norleucine methyl ester hydrochloride;H-D-Nle-OMe*HCl

Chemical Property of D-Norleucine methyl ester hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 2.17920
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98.5% ^*data from raw suppliers

D-Norleucine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-Norleucine methyl ester hydrochloride

There total 5 articles about D-Norleucine methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-amino-hexanoic acid (616-06-8) → norleucine methyl ester hydrochloride (3844-54-0,60687-33-4,77300-48-2)

Guidance literature:

With hydrogenchloride; for 18h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85141-3

Reference yield:

methyl 2-((diphenylmethylene)amino)hexanoate (203855-78-1) → norleucine methyl ester hydrochloride (3844-54-0,60687-33-4,77300-48-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 6h;

DOI:10.1021/ol990956i

Reference yield:

C20H25NO2 → norleucine methyl ester hydrochloride (3844-54-0,60687-33-4,77300-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,3-dichloro-5,6-dicyanobenzoquinone; molecular sieves 4 Angstroem / benzene / 1 h / 60 °C

2: aq. HCl / diethyl ether / 6 h

With hydrogenchloride; 4 A molecular sieve; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; benzene;

DOI:10.1021/ol990956i

upstream raw materials:

methanol

2-amino-hexanoic acid

L-Norleucine

methyl 2-((diphenylmethylene)amino)hexanoate

Downstream raw materials:

N-cinnamoyl-D,L-norleucine methyl ester

2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-hexanoic acid methyl ester

methyl 2-((diphenylmethylene)amino)hexanoate

2-[1-Benzyloxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-4-butyl-4,5-dihydro-1H-imidazole-4-carboxylic acid methyl ester

Refernces

• 1、 Han, Bao Feng,Shi, Qing Ming,Wang, Xian Feng,Liu, Jian Bo,Qiang, Sheng,Yang, Chun Long. "Synthesis and bioactivity of novel 3-(1-hydroxyethylidene)-5-substituted- pyrrolidine-2,4-dione derivatives". experimental part. p. 1023 - 1026. Retrieved 2012/10/08.
• 2、 Miyazawa, Toshifumi,Imagawa, Kiwamu,Minowa, Hiroe,Miyamoto, Toyoko,Yamada, Takashi. "Resolution of non-protein amino acids via the microbial protease-catalyzed enantioselective hydrolysis of their N-unprotected esters". . p. 10254 - 10261. Retrieved 2007/10/03.